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Results of this analysis have shown that while nevic cells display high levels of the receptor, this heterodimer undergoes a progressive decrease in expression in cutaneous melanomas of increasing invasiveness. A loss or unco\u2010ordinated expression of the \u03b11\/\u03b2 complex is present in the majority of the metastatic foci at different body sites. The present results show that during transformation the \u03b16\/\u03b21 laminin receptor undergoes quantitative alterations and deregulated expression of the 2 subunits. Although the functional relevance of these changes remains unknown, their occurrence in association with modifications of other cellular and extracellular macro\u2010molecules associated with tumor progression, strongly suggests a role in human melanoma progression.<\/jats:p>","DOI":"10.1002\/ijc.2910490203","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:19:14Z","timestamp":1171923554000},"page":"168-172","source":"Crossref","is-referenced-by-count":35,"title":["Tumor progression in human malignant melanoma is associated with changes in \u03b16\/\u03b21 laminin receptor"],"prefix":"10.1002","volume":"49","author":[{"given":"Pier Giorgio","family":"Natali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rita","family":"Nicotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Cavaliere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Giannarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Bigotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"6757","article-title":"Integrin distribution in malignant melanoma: association of the \u03b23 subunit with tumor progression","volume":"50","author":"Albelda M. 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