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While the affinity of B\u2010CLL alpha<jats:sub>2<\/jats:sub> adrenoceptors was low (K<jats:sub>D<\/jats:sub>: 9.81 nm\u201020.98 nm), each cell expressed a large number of receptors. No binding of the alpha<jats:sup>1<\/jats:sup> adrenoceptor antagonist prazosin was observed and the binding properties of beta adrenergic receptors (assayed with <jats:sup>3<\/jats:sup>H\u2010labelled dihydroalprenolol), were similar to those described for normal lymphocytes. Reaction of B\u2010CLL with the beta adrenergic agonist isoproterenol raised the levels of cAMP in 11\/13 patients tested, and in 8 of these, incubation with the alpha<jats:sub>2<\/jats:sub> adrenergic agonist clonidine prevented the effect and reduced the basal cAMP levels. The presence of active alpha<jats:sub>2<\/jats:sub> adrenoceptors on B\u2010CLL lymphocytes may be involved in the regulation of metabolic pathways that affect cell functions and favor neoplastic growth.<\/jats:p>","DOI":"10.1002\/ijc.2910490205","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:19:14Z","timestamp":1171923554000},"page":"178-181","source":"Crossref","is-referenced-by-count":15,"title":["Active alpha<sub>2<\/sub> and beta adrenoceptors in lymphocytes from patients with chronic lymphocytic leukemia"],"prefix":"10.1002","volume":"49","author":[{"given":"Juan C.","family":"Goin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonor","family":"Sterin\u2010Borda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enri S.","family":"Borda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Finiasz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria M. 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