{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:49:38Z","timestamp":1756385378760},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5425,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1991,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A hospital\u2010based case\u2010control study was conducted to assess the possible relationship between use of depot\u2010medroxy\u2010progesterone acetate (DMPA), an injectable progestational contraceptive, and the development of liver cancer in 2 developing countries where hepatitis B is endemic. Information about prior DMPA use and potential confounders was ascertained during personal interviews with 71 cases and 530 controls from 3 hospitals in Thailand and 1 hospital in Kenya. No significant association between liver cancer and DMPA use was observed in Kenya (RR = 1.64, 95% CI = 0.4\u20100.6) or Thailand (RR = 0.33, 95% CI = 0.1\u20101.O). No consistent changes in risk were observed with duration of use, time since last use, or time since first use. No significant associations were observed between DMPA use and risks of either hepatocellular carcinoma or cholangiocarcinoma. These findings suggest that risk of liver cancer in areas where hepatitis B is endemic is not appreciably altered by the use of DMPA.<\/jats:p>","DOI":"10.1002\/ijc.2910490206","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:19:14Z","timestamp":1171923554000},"page":"182-185","source":"Crossref","is-referenced-by-count":18,"title":["Depot\u2010medroxyprogesterone acetate (DMPA) and risk of liver cancer"],"prefix":"10.1002","volume":"49","author":[{"name":"THE WHO COLLABORATIVE STUDY OF NEOPLASIA AND STEROID CONTRACEPTIVES","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G.","family":"Mati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Kenya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kungu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Gatei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suporn","family":"Silpisoronkosol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tieng","family":"Pardthaisong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virote","family":"Sahapong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choti","family":"Theetranont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banpot","family":"Boosiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supawat","family":"Chutivongse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramuan","family":"Virutmasen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chansuda","family":"Wongsrchanalai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sermsri","family":"Sindhvananda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suporn","family":"Koetsawang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daungdao","family":"Rachawat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amom","family":"Koetsawang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. P.","family":"Anthony","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Noonan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta M.","family":"Ray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin A.","family":"Rosenblatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet L.","family":"Stanford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Holck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy M. M.","family":"Farley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin A.","family":"Rosenblatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"962","article-title":"A case\u2010control study of hepatocellular carcinoma","volume":"46","author":"Austin H.","year":"1986","journal-title":"Cancer Res."},{"key":"e_1_2_1_3_1","first-page":"3","article-title":"Medroxyprogesterone administration in female Marsh mice","volume":"18","author":"Bischoff F.","year":"1977","journal-title":"Proc. Amer. Soc. clin. Oncol."},{"volume-title":"Statistical methods in cancer res. Vol. 1. The analysis of case\u2010control studies","year":"1980","author":"Breslow N. E.","key":"e_1_2_1_4_1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1136\/bmj.292.6532.1357","article-title":"Cancer of the liver and the use of oral contraceptives","volume":"292","author":"Forman D.","year":"1986","journal-title":"Brit. Med. J."},{"key":"e_1_2_1_6_1","first-page":"1","volume-title":"Long\u2010acting steroid contraceptives","author":"Fraser I. S.","year":"1983"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1983.210"},{"volume-title":"IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans","year":"1979","author":"International Agency for Research on Cancer","key":"e_1_2_1_8_1"},{"volume-title":"Cancer incidence in five continents","year":"1987","author":"International Agency for Research on Cancer","key":"e_1_2_1_9_1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840110221"},{"key":"e_1_2_1_11_1","first-page":"5246","article-title":"Hepatitis B virus and cigarette smoking: risk factors for hepatocellular carcinoma in Hong Kong","volume":"42","author":"Lam K. C.","year":"1982","journal-title":"Cancer Res."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1989.94"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-71617-1_23"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1136\/bmj.292.6532.1355","article-title":"Oral contraceptives and hepatocellular carcinoma","volume":"292","author":"Neuberger J.","year":"1986","journal-title":"Brit. med. J."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115420"},{"key":"e_1_2_1_16_1","article-title":"Injectables and implants","volume":"2","author":"Population Information Program","year":"1983","journal-title":"Population Reports"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67265-1_16"},{"key":"e_1_2_1_18_1","first-page":"40","article-title":"Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association","volume":"24","author":"Szmuness W.","year":"1978","journal-title":"Prog. med. Virol."},{"volume-title":"A coded compendium of the international histological classification of tumors","year":"1978","author":"World Health Organization","key":"e_1_2_1_19_1"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910430215"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910490206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910490206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T07:55:08Z","timestamp":1698047708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910490206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,9,9]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,9,9]]}},"alternative-id":["10.1002\/ijc.2910490206"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910490206","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"type":"print","value":"0020-7136"},{"type":"electronic","value":"1097-0215"}],"subject":[],"published":{"date-parts":[[1991,9,9]]}}}