{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:33:02Z","timestamp":1790789582494,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":5405,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1991,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The human c\u2010<jats:italic>MET<\/jats:italic> oncogene encodes a transmembrane tyrosine kinase (p 190<jats:sup>c\u2010<jats:italic>met<\/jats:italic><\/jats:sup>) with structural and functional features of a growth\u2010factor receptor. Monoclonal antibodies (MAbs) have been used to investigate the distribution of the c\u2010Met protein in human normal and neoplastic tissues. By immunofluorescence microscopy homogeneous expression was detected in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Positive staining was also found in epithelial cells of the endometrium and ovary, and in basal keratinocytes of esophagus and skin. By Northern blot analysis, high levels of c\u2010<jats:italic>met<\/jats:italic> messenger RNA were detected in specimens of liver, gastro\u2010intestinal tract and kidney. c\u2010<jats:italic>met<\/jats:italic>\u2010specific mRNA was also found in thyroid, pancreas and placenta, in which organs c\u2010<jats:italic>Met<\/jats:italic> protein was barely detectable by immunofluorescence. The antibodies revealed expression of c\u2010<jats:italic>MET<\/jats:italic> protein in hepatomas (11\/14), carcinomas of colon and rectum (19\/21), stomach (11\/22), kidney (16\/19), ovary (9\/17) and skin (7\/17). Carcinomas of the lung (13\/20), thyroid (11\/13) and pancreas (5\/7) were also positive. In these last cases (lung, thyroid and pancreas) tumor cells were homogeneously stained by the antibodies, whereas in their normal counterparts staining was barely detectable. These data suggest that the receptor encoded by c\u2010<jats:italic>MET<\/jats:italic> plays a physiological role in epithelial cell growth and that its expression is altered in human carcinomas.<\/jats:p>","DOI":"10.1002\/ijc.2910490302","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:16:45Z","timestamp":1171923405000},"page":"323-328","source":"Crossref","is-referenced-by-count":212,"title":["The receptor encoded by the human C\u2010<i>MET<\/i> oncogene is expressed in hepatocytes, epithelial cells and solid tumors"],"prefix":"10.1002","volume":"49","author":[{"given":"Maria","family":"Prat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha P.","family":"Narsimhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Crepaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rita Nicotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier G.","family":"Natali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo M.","family":"Comoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1988.82"},{"key":"e_1_2_1_3_1","first-page":"4087","article-title":"Overexpression of HER\u20102\/neu is associated with poor survival in advanced epithelial ovarian cancer","volume":"50","author":"Berchuck A.","year":"1990","journal-title":"Cancer Res."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1846706"},{"key":"e_1_2_1_5_1","first-page":"593","article-title":"Characterization of the mouse met proto\u2010oncogene","volume":"2","author":"Chan A. 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Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.EMBO J.(1991b) (In press).","DOI":"10.1002\/j.1460-2075.1991.tb07836.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910450314"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.18.6379"},{"key":"e_1_2_1_27_1","first-page":"553","article-title":"C\u2010met is amplified but not mutated in a cell line with an activated met tyrosine kinase","volume":"6","author":"Ponzetto C.","year":"1991","journal-title":"Oncogene"},{"key":"e_1_2_1_28_1","first-page":"5799","article-title":"CAR\u20103, a monoclonal antibody\u2010defined antigen expressed on human carcinomas","volume":"45","author":"Prat M.","year":"1985","journal-title":"Cancer Res."},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2660(08)60549-0"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(85)80047-7"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-6164-3_10"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2470152"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3798106"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1988.150"},{"key":"e_1_2_1_35_1","first-page":"175","article-title":"Immunohistochemical detection of the neu protein in tissue sections of human breast tumors with amplified neu DNA","volume":"2","author":"Van de Vijver M. 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