{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:01:54Z","timestamp":1761742914064},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":5405,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1991,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunohistological expression of integrins has been analyzed on 45 neuroblastoma specimens representative of the different clinical and histological forms of the tumor. None of the specimens expressed the \u03b1<jats:sub>5<\/jats:sub> chain of the integrins. The \u03b2<jats:sub>1<\/jats:sub> chain was expressed on all specimens, the \u03b1<jats:sub>1<\/jats:sub> chain on 44 specimens and the \u03b1<jats:sub>3<\/jats:sub> chain on 42; the 4 specimens which lacked \u03b1<jats:sub>1<\/jats:sub> or \u03b1<jats:sub>3<\/jats:sub> were stage\u20104 neuroblastomas. The \u03b1<jats:sub>2<\/jats:sub> chain was expressed on 18 specimens, and the \u03b1<jats:sub>6<\/jats:sub> chain on 17;15 reacted with both. Their reactivity was related to the maturation of the tumor rather than the stage of the disease: they were expressed on lowgrade, well\u2010differentiated specimens; stage 3\u20104 neuroblastoma specimens analyzed at diagnosis were negative, but usually expressed both chains when analyzed after <jats:italic>in vivo<\/jats:italic> differentiation by chemotherapy. \u03b1<jats:sub>v<\/jats:sub> reacted with 18 specimens and \u03b2<jats:sub>3<\/jats:sub> with 12, without strict relation with the stage of the disease and\/or its degree of differentiation; 9 well\u2010differentiated specimens expressed the \u03b2<jats:sub>4<\/jats:sub> chain; only 4 well\u2010differentiated specimens expressed the \u03b1<jats:sub>4<\/jats:sub> chain. The 4 specimens which lacked \u03b1<jats:sub>1<\/jats:sub>\u2010\u03b2<jats:sub>1<\/jats:sub> or \u03b1<jats:sub>3<\/jats:sub>\u2010\u03b2<jats:sub>1<\/jats:sub> expression had n\u2010<jats:italic>myc<\/jats:italic> amplification, whereas those which expressed either \u03b1<jats:sub>4<\/jats:sub>, \u03b2<jats:sub>4<\/jats:sub>, \u03b2<jats:sub>3<\/jats:sub>, or \u03b1<jats:sub>v<\/jats:sub> had no amplification. Furthermore, the expression of the 3 heterodimers \u03b1<jats:sub>4<\/jats:sub>\u2010\u03b2<jats:sub>1<\/jats:sub>, \u03b1<jats:sub>v<\/jats:sub>\u2010\u03b2<jats:sub>3<\/jats:sub> and \u03b1<jats:sub>6<\/jats:sub>\u2010\u03b2<jats:sub>4<\/jats:sub> was essentially observed on primary tumors which developed in the mediastinum. The expression of \u03b1<jats:sub>2<\/jats:sub>\u2010\u03b2<jats:sub>1<\/jats:sub> and \u03b1<jats:sub>6<\/jats:sub>\u2010\u03b2<jats:sub>1<\/jats:sub> was observed on both n\u2010<jats:italic>myc<\/jats:italic>\u2010positive and \u2010negative specimens. \u03b2<jats:sub>1<\/jats:sub> and \u03b1<jats:sub>3<\/jats:sub>, were diffusely expressed on all counterparts of these tumors, from undifferentiated neuroblasts to ganglion and Schwann cells. The \u03b1<jats:sub>1<\/jats:sub> chain reacted with undifferentiated and intermediate neuroblasts as well as with Schwann cells, but ganglion cells were negative. \u03b1<jats:sub>2<\/jats:sub> and \u03b1<jats:sub>6<\/jats:sub> chains were negative on undifferentiated neuroblasts, variably expressed on intermediate neuroblasts, and restricted to Schwann cells in ganglioneuroma. The expression of \u03b1<jats:sub>4<\/jats:sub> and \u03b2<jats:sub>4<\/jats:sub> was restricted to Schwann cells. \u03b1<jats:sub>v<\/jats:sub> and \u03b2<jats:sub>3<\/jats:sub> occasionally reacted with undifferentiated and intermediate neuroblasts; \u03b1<jats:sub>v<\/jats:sub> was strongly positive on Schwann cells but negative on ganglion cells, whereas \u03b2<jats:sub>3<\/jats:sub> was positive on both neuronal and non\u2010neuronal populations.<\/jats:p>","DOI":"10.1002\/ijc.2910490306","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:16:45Z","timestamp":1171923405000},"page":"347-355","source":"Crossref","is-referenced-by-count":30,"title":["Expression of integrin receptors on 45 clinical neuroblastoma specimens"],"prefix":"10.1002","volume":"49","author":[{"given":"Marie C.","family":"Favrot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Combaret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Goillot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Frappaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Thiesse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Thyss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Dolbeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Bouffet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Tabone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Philip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810115)47:2<373::AID-CNCR2820470227>3.0.CO;2-O"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.4.11.2199285"},{"key":"e_1_2_1_4_1","first-page":"6757","article-title":"Integrin distribution in malignant melanoma: association of the \u03b23 subunit with tumor progression","volume":"50","author":"Albelda S. 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