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The MAb to the early protein reacted with cells infected with 14 different HHV\u20106 isolates. In contrast, the MAb against the late protein reacted with only 10 of these isolates, indicating that there was strain variation in this glycoprotein. The percentage of antibody\u2010positive sera reactive with gp110 in the ELISA ranged from 56% to 96% among the different serum donor categories. In contrast, only 10\u201030% of the sera were positive for antibodies to p41\/38 with the exception of sera from patients with African Burkitt's lymphoma (ABL) and Hodgkin's disease (HD). These antibody patterns denote the presence of active HHV\u20106 replication in patients with ABL and HD.<\/jats:p>","DOI":"10.1002\/ijc.2910490413","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:26:57Z","timestamp":1171924017000},"page":"551-557","source":"Crossref","is-referenced-by-count":39,"title":["Sero\u2010epidemiological investigations on human herpesvirus 6 (HHV\u20106) infections using a newly developed early antigen assay"],"prefix":"10.1002","volume":"49","author":[{"given":"Sujatha","family":"Iyengar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul H.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dharam","family":"Ablashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Neequaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary R.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910420526"},{"key":"e_1_2_1_3_1","first-page":"193","article-title":"Human herpesvirus\u20106 (HHV\u20106)","volume":"5","author":"Ablashi D. 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