{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T12:42:09Z","timestamp":1698064929926},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":5363,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1991,11,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cellular immune responses to Epstein\u2010Barr Virus (EBV)\u2010associated antigens play an important role in the control of EBV\u2010immortalized B lymphocytes. The nature of the antigens that serve as targets for these responses remains largely unknown. The purpose of the experiments reported here was to determine if virus\u2010replication\u2010associated antigens might function as targets for T\u2010cell immunity with the emphasis on EBV\u2010induced early antigen (EA) complex. Activated T\u2010cell populations directed against this group of antigens would theoretically be effective in controlling the production of new virus progeny. Our results demonstrate that polypeptides associated with the EA complex do, in fact, induce the proliferation of memory T\u2010cells from EBV\u2010infected individuals irrespective of their serological status to the EA complex. The major polypeptide associated with the diffuse component of EA (EA\u2010D) was notably effective in inducing a strong proliferative T\u2010cell response. Cell lines established from EBV\u2010infected individuals following continuous exposure to either p17 or p50 components of the EA complex over a 10\u2010 to 12\u2010week period were composed primarily of CD4\u2010positive T\u2010cells, although CD8\u2010positive cells also persisted for up to 9 weeks in culture. The data suggest that components of the EA complex might function as important target antigens in the immunosurveillance of EBV\u2010infected cells.<\/jats:p>","DOI":"10.1002\/ijc.2910490505","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:47:04Z","timestamp":1171925224000},"page":"656-660","source":"Crossref","is-referenced-by-count":8,"title":["Human T\u2010cell recognition of epstein\u2010barr virus\u2010induced replication antigen complexes"],"prefix":"10.1002","volume":"49","author":[{"given":"Susan","family":"Pothen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Richert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary R.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4049\/jimmunol.146.1.257","article-title":"Equivalent recognition of a varicella\u2010zoster virus immediate early protein (IE 62) and glycoprotein I by cytotoxic T lymphocytes of either CD4+ or CD8+ phenotype","volume":"146","author":"Arvin A. 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