{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:49:46Z","timestamp":1789728586099,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":5363,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1991,11,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The expression of the haeme\u2010binding protein, lactoferrin, was studied in human gastric tissues displaying normal, benign hyperplastic or malignant histology. A single 2.5\u2010kb mRNA was detected in only 14% (2\/14) of normal resections. This was similar to the finding that 85% of tumours were also negative, with 4\/27 positive. In contrast, samples with superficial or atrophic gastritis had a high frequency of expression, with 5\/7 and 9\/14 positive respectively. The higher incidence of lactoferrin mRNA in antral samples was a reflection of the greater proportion of these compared with body resections of patients with gastritis. No expression was seen in any of 5 gastric carcinoma cell lines. High levels were observed in the cardia, in contrast to complete absence in the oesophagus. Immunocytochemistry showed localization of lactoferrin in cells of both antral and body glands. Chief cells, but not adjacent parietal cells, were strongly stained. In tissues exhibiting superficial or atrophic gastritis we observed a greater degree and intensity of staining as compared with samples with normal histology. We also observed some staining of tumour cells, though this was very patchy. Lactoferrin may have a role in mucosal iron transport in both normal and highly proliferating tissue, but does not appear to be significantly associated with malignant lesions.<\/jats:p>","DOI":"10.1002\/ijc.2910490510","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:47:04Z","timestamp":1171925224000},"page":"684-687","source":"Crossref","is-referenced-by-count":26,"title":["Expression of lactoferrin in human stomach"],"prefix":"10.1002","volume":"49","author":[{"given":"Y. A.","family":"Luqmani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. A.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bennet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. C.","family":"Coombes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. M.","family":"Paterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02639770"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb1961.53.31"},{"key":"e_1_2_1_4_1","first-page":"2104","article-title":"Expression of growth\u2010factor and epidermal\u2010growth\u2010factor\u2010receptor\u2010encoded transcripts in human gastric tissues","volume":"49","author":"Bennett C.","year":"1989","journal-title":"Cancer Res."},{"key":"e_1_2_1_5_1","first-page":"781","article-title":"The role of lactoferrin in the bacteriocidal function of polymorphonuclear leucocytes","volume":"36","author":"Bullen J. J.","year":"1979","journal-title":"Immunology"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00591a005"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_1_8_1","first-page":"132","article-title":"Determination of lactoferrin in the diagnosis of disease of the pancreas","volume":"35","author":"Dite P.","year":"1989","journal-title":"Vnitr. Lek."},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.2527\/jas1984.5941080x","article-title":"Isolation of lactoferrin and its concentration in sow's colostrum and milk during a 21\u2010day lactation","volume":"59","author":"Elliot J. I.","year":"1984","journal-title":"J. Animal Sci."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.2.415"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-103-4-1510"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.12.6406"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(83)90099-X"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/23.12.1104708"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910440510"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/10.24.7895"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.31.4.316"},{"key":"e_1_2_1_18_1","first-page":"119","article-title":"Lactoferrin in milk from different species","volume":"39","author":"Masson P. L.","year":"1971","journal-title":"Comp. Biochem. Physiol."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(66)90004-0"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132496"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2290353"},{"key":"e_1_2_1_22_1","first-page":"65","article-title":"Comparison of seven cell lines derived from human gastric carcinomas","volume":"36","author":"Motoyama T.","year":"1986","journal-title":"Acta. path. jap."},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"10134","DOI":"10.1016\/S0021-9258(18)61088-9","article-title":"Lactotransferrin is the major estrogen\u2010inducible protein of mouse uterine secretions","volume":"262","author":"Pentecost B. T.","year":"1987","journal-title":"J. biol. Chem."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V64.5.1103.1103"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1182\/blood.V70.4.989.989","article-title":"Isolation of lactoferrin cDNA from a human myeloid library and expression of mRNA during normal and leukaemic myelopoiesis","volume":"70","author":"Rado T. A.","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1989.tb15218.x"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910270311"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-124-2-992"},{"key":"e_1_2_1_29_1","first-page":"912","article-title":"Immunocytochemical detection of lactoferrin in human gastric carcinomas and adenomas","volume":"113","author":"Tuccari G.","year":"1989","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1182\/blood.V70.1.264.264","article-title":"Lactoferrin binding by leukemia cell lines","volume":"70","author":"Yamado Y.","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.25.1.1"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910490510","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910490510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T01:20:28Z","timestamp":1698024028000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910490510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11,11]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1991,11,11]]}},"alternative-id":["10.1002\/ijc.2910490510"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910490510","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,11,11]]}}}