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Antibody against HTLV\u20101 was detected at the 5th week after MT\u20102 injection, and its titer reached a high plateau which continued from the 15th to the 27th week. The antibodies were against p 19, p24, p28 and p53 of HTLV\u20101 antigens from MT\u20102 cells. The gag, pX and LTR nucleotide sequences of HTLV\u20101 provirus were demonstrated by using polymerase chain reaction (PCR) in the peripheral\u2010blood mononuclear cells of 3 rats at the 44th week and 2 at the 66th to 68th week out of 8 F344 rats injected with MT\u20102 cells. Quantification of the HTLV\u20101 proviral sequence revealed that 30 to 60 molecules were present in 10<jats:sup>5<\/jats:sup> peripheral\u2010blood mononuclear cells, indicating that the rats were chronically infected with HTLV\u20101. HTLV\u20101\u2010infected rats could serve as a small\u2010animal model for studying the pathophysiological state of HTLV\u20101 carriers and also that of HTLV\u20101 infection on various HTLV\u20101\u2010related diseases, including adult T\u2010cell leukemia and HTLV\u20101\u2010associated myelopathy.<\/jats:p>","DOI":"10.1002\/ijc.2910490522","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:47:04Z","timestamp":1171925224000},"page":"764-769","source":"Crossref","is-referenced-by-count":45,"title":["Infection of rats with HTLV\u20101: A small\u2010animal model for HTLV\u20101 carriers"],"prefix":"10.1002","volume":"49","author":[{"given":"T.","family":"Suga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kameyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Shimotohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kushida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"86","article-title":"Experimental infection of rabbits with human T\u2010cell leukemia virus type I","volume":"76","author":"Akagi T.","year":"1985","journal-title":"Jap. 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