{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:09Z","timestamp":1761058629469},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,21]],"date-time":"2006-07-21T00:00:00Z","timestamp":1153440000000},"content-version":"vor","delay-in-days":5346,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u03b2<jats:sub>1<\/jats:sub>\u2010Integrins (VLA\u20101 to \u20106) are cell\u2010surface molecules binding to matrix molecules such as collagen, fibronectin and laminin. VLA\u20104 is the human homologue to the murine Peyer's patch homing receptor mediating cell\/cell adhesion required for lymphocyte extravasation or \u201choming\u201d. Other structures which have a homing\u2010receptor function through recognition of venular endothelium are H\u2010CAM (CD44) and LECAM\u20101 (LAM\u2010 1, human MEL\u201014 equivalent). In order to elucidate whether these adhesion receptors are expressed in primary gastro\u2010intestinal malignant B\u2010cell lymphomas (GI BmL) which, in this case, might contribute to the initial confinement to this extranodal site, 31 extensively characterized tumors were examined together with reactive lymphoid tissues from small and large intestine, tonsil and lymph node using monoclonal antibodies (MAbs) against these receptors. All types of adhesion receptors were differentially expressed in the cytologically and microtopographically defined B\u2010cell subsets [follicular center cells (FC), mantle\u2010zone cells (MZ), extrafollicular cells (EF) and plasma cells (PC)] of the normal B\u2010cell system. With the exception of differences in LECAM\u20101 levels among EF and PC of intestinal <jats:italic>vs.<\/jats:italic> nodal <jats:italic>vs.<\/jats:italic> tonsillar sites, receptor profiles were almost identical in different lymphoid organs. The expression pattern of these molecules in GI BmL was markedly heterogeneous, mimicking to some extent the receptor equipment of their reactive cellular counterpart. Thus, we failed to find a unifying adhesion receptor profile indicative of a tissue\u2010specific homing of reactive and neoplastic B\u2010cells.<\/jats:p>","DOI":"10.1002\/ijc.2910490608","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:46:59Z","timestamp":1171925219000},"page":"846-855","source":"Crossref","is-referenced-by-count":21,"title":["Expression of \u03b21\u2010integrins, H\u2010CAM (CD44) and LECAM\u20101 in primary gastro\u2010intestinal B\u2010cell lymphomas as compared to the adhesion receptor profile of the gut\u2010associated lymphoid system, tonsil and peripheral lymph node"],"prefix":"10.1002","volume":"49","author":[{"given":"Peter","family":"M\u00f6ller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anette","family":"Eichelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunhild","family":"Mechtersheimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Koretz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1986.tb01948.x"},{"key":"e_1_2_1_3_1","first-page":"1","volume-title":"Immunology of the gastrointestinal tract","author":"Brandtzaeg P.","year":"1987"},{"key":"e_1_2_1_4_1","first-page":"442","article-title":"Lymphocyte activation and expression of the human leucocyte\u2010endothelial cell adhesion molecule 1 (Leu\u20108\/TQ1 antigen)","volume":"71","author":"B\u00fchrer C.","year":"1990","journal-title":"Immunology"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.3.763"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711540205"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90092-D"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.111.6.2765"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.1.224"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/304030a0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.4049\/jimmunol.144.9.3361","article-title":"Human B lymphocytes define an alternative mechanism of adhesion to fibronectin. 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