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The presence of the enzyme was demonstrated on the cell membranes of interlobular fibroblasts, whilst intralobular fibroblasts were DPP\u2010IV\u2010negative. A fluorograph, after immunoprecipitation of <jats:sup>35<\/jats:sup>S\u2010methionine\u2010labelled proteins of fibroblasts from primary breast cultures with an anti\u2010serum to DPP IV, demonstrated a band at 135 kDa consistent with the presence of the enzyme. The clear delineation of 2 functionally distinct sub\u2010populations of breast fibroblasts was maintained in benign fibro\u2010adenomas and cystosarcoma phyllodes, both tumour types having growth characteristics of intralobular stroma. This observation has important implications for both normal breast biology and for breast carcinogenesis.<\/jats:p>","DOI":"10.1002\/ijc.2910500105","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:43:20Z","timestamp":1171925000000},"page":"15-19","source":"Crossref","is-referenced-by-count":46,"title":["Dipeptidyl peptidase iv expression identifies a functional sub\u2010population of breast fibroblasts"],"prefix":"10.1002","volume":"50","author":[{"given":"Amanda J.","family":"Atherton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Monaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Warburton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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