{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:05:57Z","timestamp":1790247957583,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5310,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1992,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An experimental rabbit model was used to determine host responses to infection by various human T\u2010lymphotropic virus type\u2010I (HTLV\u2010I) strains. Seven groups of 4 to 5 rabbits each were inoculated with lethally\u2010irradiated HTLV\u2010I\u2010infected cell lines derived from patients with adult T\u2010cell leukemia\/lymphoma or from patients with HTLV\u2010I\u2010associated myelopathy. Four separate control groups of 2 rabbits each were inoculated with similarly prepared HTLV\u2010I\u2010negative cells derived from rabbits or humans. Anti\u2010viral antibody responses were assessed by immunoblot assay and hematologic parameters were measured using automated cell counters and cytologic staining. The virologic status of challenged rabbits was determined by co\u2010culture and HTLV\u2010I antigen capture assay, as well as by polymerase chain reaction (PCR) amplification of HTLV\u2010I DNA from peripheral blood mononuclear cells (PBMC) or tissues. The HTLV\u2010I inocula could be separated into groups based upon their infectivity to rabbits: highly infectious strains elicited intense serologic responses and were detected frequently in tissues by antigen and PCR assays, while other strains were moderately to poorly infectious, induced weak antibody responses and were infrequently detected by antigen and PCR assays. Overall, PBMC appeared to have the greatest quantity of HTLV\u2010I containing cells, while bone marrow was a poor source of virus. No clinical or hematologic abnormalities were evident during the 24\u2010week course of infection. Taken together, our results suggest there is heterogeneity in the biological response to HTLV\u2010I infection which is, in part, dependent on the infecting strain of virus.<\/jats:p>","DOI":"10.1002\/ijc.2910500125","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:43:20Z","timestamp":1171925000000},"page":"124-130","source":"Crossref","is-referenced-by-count":36,"title":["Comparative biological responses of rabbits infected with human T\u2010lymphotropic virus type I isolates from patients with lymphoproliferative and neurodegenerative disease"],"prefix":"10.1002","volume":"50","author":[{"given":"Michael D.","family":"Lairmore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Rovnak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Glade","family":"Weiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary L.","family":"Cockerell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"736","article-title":"Licensure of screening tests for antibody to human T\u2010lymphotropic virus type 1","volume":"37","author":"Anderson D.","year":"1988","journal-title":"Morbid. Mortal. weekly Rep."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0705-1_21"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910450123"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1128\/jvi.64.3.1278-1282.1990","article-title":"Sequence variants of human T\u2010cell lymphotropic virus type I from patients with tropical spastic paraparesis and adult T\u2010cell leukemia do not distinguish neurological from leukemic isolates","volume":"64","author":"Daenke S.","year":"1990","journal-title":"J. Virol."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90692-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/17.5.2142"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.22.8526"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V55.3.409.409"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1128\/jcm.28.4.646-650.1990","article-title":"Characterization of antibody reactivity to human T\u2010cell lymphotropic virus types 1 and 2 using immunoblot and radioimmunoprecipitation assays","volume":"28","author":"Hartley T.","year":"1990","journal-title":"J. clin. Microbiol."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910450534"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/154.5.851"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.2_Part_1.192"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/163.2.252"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910370608"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0308-2261(18)30008-0","article-title":"Adult T\u2010cell leukemia\/lymphoma","volume":"15","author":"Kuefler P.","year":"1986","journal-title":"Clin. Haematol."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.22.8840"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-69-7-1695"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.6.831"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220507"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/294770a0"},{"key":"e_1_2_1_24_1","first-page":"1","article-title":"Transformation of rabbit lymphocytes with adult T\u2010cell leukemia virus","volume":"74","author":"Miyoshi I.","year":"1983","journal-title":"Jap. J. Cancer Res."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410260405"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1984.tb00083.x"},{"key":"e_1_2_1_27_1","first-page":"213","volume-title":"HTLV\u2010I and the nervous system","author":"Osame M.","year":"1989"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91298-5"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3336784"},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.4049\/jimmunol.142.3.971","article-title":"Mapping the immunogenic regions of human T cell leukemia virus type 1 (HTLV\u20101) gp46 and gp21 envelope glycoproteins with env\u2010encoded synthetic peptides and a monoclonal antibody to gp46","volume":"142","author":"Palker T.","year":"1989","journal-title":"J. Immunol."},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1128\/jcm.28.5.949-955.1990","article-title":"Immunodetection of human T\u2010cell lymphotropic virus type 1 core protein in biological samples by using a monoclonal antibody immunoassay","volume":"28","author":"Papsidero L.","year":"1990","journal-title":"J. clin. Microbiol."},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1128\/jvi.54.3.781-790.1985","article-title":"Nucleotide sequence analysis of a variant of human T\u2010cell leukemia virus (HTLV\u2010Ib) provirus with a deletion in pX\u2010I","volume":"54","author":"Ratner L.","year":"1985","journal-title":"J. Virol."},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830340312"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02660.x"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.4.1446"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410260304"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910500125","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910500125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T12:03:32Z","timestamp":1698149012000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910500125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1,2]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1,2]]}},"alternative-id":["10.1002\/ijc.2910500125"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910500125","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1,2]]}}}