{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T06:49:21Z","timestamp":1700030961192},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5291,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1992,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinico\u2010pathologic features of 107 adult Chinese patients with peripheral T\u2010cell lymphoma (excluding primary cutaneous lymphoma) are described and a comparison between HTLV\u2010I<jats:sup>+<\/jats:sup> and HTLV\u2010I<jats:sup>\u2212<\/jats:sup>patients is made. There were 27 HTLV\u2010I<jats:sup>+<\/jats:sup> and 80 HTLV\u2010I<jats:sup>\u2212<\/jats:sup>patients. The virus\u2010positive and\u2010negative groups both had a male predominance and an identical median age of 48. Most patients in both groups presented with stage\u2010IV disease, B symptoms, lymphadenopathy and hepatosplenomegaly. The HTLV\u2010I<jats:sup>+<\/jats:sup> group had a significantly higher incidence of skin and pulmonary lesions, bone marrow and peripheral blood involvement, hypercalcemia, and elevated LDH level compared to the HTLV\u2010I<jats:sup>\u2212<\/jats:sup>group. Sinonasal lesions (10), mediastinal mass (5), and GI tract involvement (6) were only seen in the HTLV\u2010I<jats:sup>\u2212<\/jats:sup>group. Leukocytosis with the presence of circulating pleomorphic lymphoid cells was characteristic of HTLV\u2010I<jats:sup>+<\/jats:sup> cases, while cytopenia was more frequently present in HTLV\u2010I<jats:sup>\u2212<\/jats:sup>cases. All of the 24 HTLV\u2010I<jats:sup>+<\/jats:sup> patients tested were CD4<jats:sup>+<\/jats:sup>CD8<jats:sup>\u2212<\/jats:sup>; of the 67 HTLV\u2010I<jats:sup>\u2212<\/jats:sup>patients tested, 46 were CD4<jats:sup>+<\/jats:sup>CD8<jats:sup>\u2212<\/jats:sup>, 9 were CD4<jats:sup>\u2212<\/jats:sup>CD8<jats:sup>+<\/jats:sup>, 5 were CD4<jats:sup>\u2212<\/jats:sup>CD8<jats:sup>\u2212<\/jats:sup>and 7 were CD4<jats:sup>+<\/jats:sup>CD8<jats:sup>+<\/jats:sup>. Phenotypic studies revealed significant differences in the expression of CD7 and CD25 between virus\u2010positive and\u2010negative groups. Both groups responded poorly to therapy. The median survival of HTLV\u2010I+ and HTLV\u2010I<jats:sup>\u2212<\/jats:sup>patients was 4 months and 13.5 months, respectively. Apart from the presence of more than 3 extranodal lesions, none of the other clinical features or histologic subtypes had prognostic significance in the entire group or either of the subgroups. This series of peripheral T\u2010cell lymphomas in Taiwan indicate that HTLV\u2010I<jats:sup>+<\/jats:sup> and HTLV\u2010I<jats:sup>\u2212<\/jats:sup>patients had many features in common, but presented several distinct differences.<\/jats:p>","DOI":"10.1002\/ijc.2910500205","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:43:13Z","timestamp":1171924993000},"page":"186-191","source":"Crossref","is-referenced-by-count":3,"title":["HTLV\u2010I\u2010positive and HTLV\u2010I\u2010negative peripheral T\u2010cell lymphomas in Taiwan Chinese"],"prefix":"10.1002","volume":"50","author":[{"given":"Lee\u2010Yung","family":"Shih","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tseng\u2010Long","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiumn\u2010Jen","family":"Liaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890101)63:1<158::AID-CNCR2820630125>3.0.CO;2-B"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90056-9"},{"key":"e_1_2_1_4_1","first-page":"415","article-title":"Utilization of monoclonal antibody L26 in the identification and confirmation of B\u2010cell lymphomas: a sensitive and specific marker applicable to formalin\u2010and B5\u2010fixed, paraffin\u2010embedded tissues","volume":"129","author":"Cartun R. 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