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The expression of IGF\u2010I and IGF\u2010II mRNAs in the tumor cells was accompanied by the co\u2010expression of their respective type\u2010I and type\u2010II IGF receptor mRNAs. Control, non\u2010malignant human brain expressed IGF\u2010I mRNA and IGF\u2010I and IGF\u2010II receptor mRNAs. There was no significant expression of IGF\u2010II mRNA in the control brain specimens. Control pachymeninges (dura mater) expressed low levels of IGF\u2010I mRNA and IGF\u2010I receptor mRNA. There was no significant expression of IGF\u2010II and IGF\u2010II receptor mRNAs in pachymeninges. The co\u2010expression of IGFs and their receptors in brain tumors may contribute in their development and maintenance. The strong inappropriate expression of IGF\u2010II mRNA and its protein product in the tumor cells of astrocytomas and meningiomas, but not in normal brain specimens, may serve as molecular markers for the early detection of these tumors.<\/jats:p>","DOI":"10.1002\/ijc.2910500210","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:43:13Z","timestamp":1171924993000},"page":"215-222","source":"Crossref","is-referenced-by-count":102,"title":["Expression of insulin\u2010like growth factors I and II and their receptor mRNAs in primary human astrocytomas and meningiomas; <i>in vivo<\/i> studies using <i>in situ<\/i> hybridization and immunocytochemistry"],"prefix":"10.1002","volume":"50","author":[{"given":"Harry N.","family":"Antoniades","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theofanis","family":"Galanopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"Neville\u2010Golden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Maxwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(84)90202-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.2.565"},{"key":"e_1_2_1_4_1","first-page":"145","article-title":"Platelet\u2010derived growth factor: a link to malignant transformation","volume":"3","author":"Antoniades H. 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