{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:16:48Z","timestamp":1764688608677},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5280,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>By using PCR amplification and oligonucleotide mismatch hybridization, base\u2010substitution mutations of the <jats:italic>ras<\/jats:italic> genes in 26 skin tumors of Japanese xeroderma pigmentosum (XP) patients were studied. Thin sections of tumor tissues which were fixed and embedded in paraffin blocks were used in this study. After analyzing codons 12, 13 and 61 of the H\u2010, K\u2010 and N\u2010<jats:italic>ras<\/jats:italic> genes by using 66 oligomer probes, we detected only one mutation of the K\u2010<jats:italic>ras<\/jats:italic> gene at codon 61 in one tumor sample. All the other tumors were therefore considered not to have a mutation in the <jats:italic>ras<\/jats:italic> genes. These results suggest that mutations of the ras genes are not particularly associated with skin tumors of Japanese XP patients.<\/jats:p>","DOI":"10.1002\/ijc.2910500309","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:43:17Z","timestamp":1171924997000},"page":"382-385","source":"Crossref","is-referenced-by-count":10,"title":["Infrequent mutation of the <i>ras<\/i> genes in skin tumors of xeroderma pigmentosum patients in Japan"],"prefix":"10.1002","volume":"50","author":[{"given":"Kanji","family":"Ishizaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Tsujimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanao","family":"Nakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikako","family":"Nishigori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Kurimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadao","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mituo","family":"Ikenaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(88)90004-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8817(83)90004-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.16.6372"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(91)90533-C"},{"key":"e_1_2_1_6_1","first-page":"1632","article-title":"Activated ras alleles in human carcinoma of the prostate are rare","volume":"51","author":"Gumerlock P. H.","year":"1991","journal-title":"Cancer Res."},{"key":"e_1_2_1_7_1","first-page":"1229","article-title":"Establishment and characterization of a melanoma cell line from a xeroderma pigmentosum patient: activation of N\u2010ras at a potential pyrimidine aimer site","volume":"49","author":"Keijzer W.","year":"1989","journal-title":"Cancer Res."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660260111026"},{"key":"e_1_2_1_9_1","first-page":"120","volume-title":"Biology of radiation carcinogenesis","author":"Maher V. M.","year":"1976"},{"key":"e_1_2_1_10_1","volume-title":"Molecular cloning: a laboratory manual","author":"Maniatis T.","year":"1982"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(85)90026-9"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-7992(85)80018-X"},{"key":"e_1_2_1_13_1","first-page":"1596","article-title":"Low frequency of ras gene mutations in neuroblastomas, pheochromocytomas and medullary thyroid cancers","volume":"51","author":"Moley J. F.","year":"1991","journal-title":"Cancer Res."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2430313"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.1.225"},{"key":"e_1_2_1_16_1","first-page":"1223","article-title":"Activated oncogenes in human skin tumors from a repair\u2010deficient syndrome, xeroderma pigmentosum","volume":"49","author":"Suarez H. G.","year":"1989","journal-title":"Cancer Res."},{"key":"e_1_2_1_17_1","first-page":"490","article-title":"DNA repair characteristics and skin cancers of xeroderma pigmentosum patients in Japan","volume":"37","author":"Takebe H.","year":"1977","journal-title":"Cancer Res."},{"key":"e_1_2_1_18_1","first-page":"1135","article-title":"Genetics and skin cancer of xeroderma pigmentosum in Japan","volume":"78","author":"Takebe H.","year":"1987","journal-title":"Jap. J. Cancer Res."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12874504"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(86)90335-5"},{"key":"e_1_2_1_21_1","first-page":"4911","article-title":"No evidence for point mutations in codons 12, 13 and 61 of the ras gene in a high\u2010incidence area for esophageal and gastric cancers","volume":"50","author":"Victor T.","year":"1990","journal-title":"Cancer Res."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910500309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910500309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T21:24:26Z","timestamp":1695849866000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910500309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,2]]}},"alternative-id":["10.1002\/ijc.2910500309"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910500309","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,2]]}}}