{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:08:46Z","timestamp":1764781726708},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5261,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1992,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The most common cancer in Egypt is urinary\u2010bladder carcinoma, which is strongly associated with infection with <jats:italic>Schistosomo haematobium.<\/jats:italic> The object of this study was to determine whether infection with this parasite resulted in an increase in chromosomal breakage in the urothelium. Urine samples were collected from 37 Egyptian farmers with <jats:italic>S. haematobium<\/jats:italic> ova in their urine and from 32 non\u2010infected males attending the same village clinic. The urine was centrifuged and the urothelial cells present in the sediment were assayed for the presence of micronuclei, a quantitative indicator of chromosomal breakage. Micronucleus frequencies were significantly higher in the infected group (mean frequency, 0.97 \u00b1 0.12%) than among controls (mean frequency, 0.12 \u00b1 0.04%, <jats:italic>p<\/jats:italic> &lt; 0.001). There was a trend towards an increase in micronucleus frequencies in infected individuals who smoked (10 of the 37 subjects) compared with those who were non\u2010smokers, although this effect was not significant (<jats:italic>p<\/jats:italic> = 0.12). Bladder infection was associated with a 6.8\u2010fold increase in micronucleus frequencies among non\u2010smokers. In a pilot study, 11 patients were treated with praziquantel, an anti\u2010schistosomal agent. Mean micronucleus frequencies were reduced significantly (before treatment, 1.27 \u00b1 0.16%; after treatment, 0.30 \u00b1 0.16%, <jats:italic>p<\/jats:italic> &lt; 0.001), thus supporting a direct involvement of the infection in increased chromosomal breakage in the urothelium.<\/jats:p>","DOI":"10.1002\/ijc.2910500407","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:39:12Z","timestamp":1171924752000},"page":"539-543","source":"Crossref","is-referenced-by-count":31,"title":["Chromosomal damage in urothelial cells from egyptians with chronic <i>Schistosoma haematobium<\/i> infections"],"prefix":"10.1002","volume":"50","author":[{"given":"Miriam P.","family":"Rosin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wagida","family":"Anwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.19.7772"},{"key":"e_1_2_1_3_1","unstructured":"Bartsch H. Ohshima H. Pignatelli B.andCalmels S. Human exposure to endogenous N\u2010nitroso compounds: quantitative estimates in subjects at high risk for cancer of the oral cavity oesophagus stomach and urinary bladder. In: D. Forman and D. Shuker (eds.) Cancer surveys: nitrate nitrite and nitroso compounds in human cancer Vol. 8 pp.335\u2013362 (1989)."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2981433"},{"key":"e_1_2_1_5_1","first-page":"307","article-title":"Increased incidence of hepatoma in mice with chronic Schistosomiasis mansoni treated with a carcinogen","volume":"51","author":"Domingo E. O.","year":"1967","journal-title":"Amer. J. Pathol."},{"key":"e_1_2_1_6_1","first-page":"9","volume-title":"Detection of bladder cancer associated with Schistosomiasis","author":"El\u2010Sebai I. T.","year":"1981"},{"key":"e_1_2_1_7_1","first-page":"1482","article-title":"Increased susceptibility to low doses of a carcinogen of epidermal cells in stimulated DNA synthesis","volume":"27","author":"Frei J. V.","year":"1967","journal-title":"Cancer Res."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(81)90113-2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5496-3_13"},{"key":"e_1_2_1_10_1","first-page":"455","volume-title":"Nitrosamines and human cancer","author":"Hicks R. M.","year":"1982"},{"key":"e_1_2_1_11_1","first-page":"644","article-title":"Numerical chromosome 1, 7, 9, and 11 aberrations in bladder cancer detected by in situ hybridization","volume":"51","author":"Hopman A. H. N.","year":"1991","journal-title":"Cancer Res."},{"key":"e_1_2_1_12_1","first-page":"115","article-title":"The Schistosomiasis problem in the world: results of a WHO questionnaire survey","volume":"59","author":"Iarotski L. S.","year":"1981","journal-title":"Bull. WHO"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.2739\/kurumemedj.32.169"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113768"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(87)90341-3"},{"key":"e_1_2_1_16_1","first-page":"233","volume-title":"Skin carcinogenesis: mechanisms and human relevance","author":"Kensler T. W.","year":"1989"},{"key":"e_1_2_1_17_1","first-page":"629","article-title":"Genital and urinary tract disease and bladder cancer","volume":"51","author":"La Vecchia C.","year":"1991","journal-title":"Cancer Res."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1974.238"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx00005a001"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(88)90025-1"},{"key":"e_1_2_1_21_1","first-page":"384","volume-title":"The relevance of N\u2010nhroso compounds in human cancer: exposures and mechanism","author":"Ohshima H.","year":"1987"},{"key":"e_1_2_1_22_1","first-page":"7415","article-title":"Increased cell division as a cause of human cancer","volume":"50","author":"Preston\u2010Martin S.","year":"1990","journal-title":"Cancer Res."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02139219"},{"key":"e_1_2_1_24_1","first-page":"45","article-title":"Antigenotoxic action of carotenoids in carcinogen\u2010exposed populations","volume":"52","author":"Rosin M. P.","year":"1990","journal-title":"Basic Life Sci."},{"key":"e_1_2_1_25_1","unstructured":"Rosin M. P. Genetic and proliferation markers in clinical studies of the premalignant process.Cancer Bull. (1991) (In press)."},{"key":"e_1_2_1_26_1","volume-title":"The Fayoum cancer registry","author":"Sherif M.","year":"1987"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90028-8"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910310309"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(84)90159-9"},{"key":"e_1_2_1_30_1","first-page":"197","volume-title":"Unusual occurrences as clues to cancer etiology","author":"Tawfik H. N.","year":"1988"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/10.3.547"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498259009046908"},{"key":"e_1_2_1_33_1","first-page":"44","article-title":"Allelic losses of chromosomes 9, 11 and 17 in human bladder cancer","volume":"50","author":"Tsai Y. C.","year":"1990","journal-title":"Cancer Res."},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.283.6299.1104"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1989073"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.4.655.655"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910500407","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910500407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T21:34:58Z","timestamp":1695850498000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910500407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2,20]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,2,20]]}},"alternative-id":["10.1002\/ijc.2910500407"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910500407","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,2,20]]}}}