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Despite the massive presence of tumor\u2010infiltrating lymphocytes, NPC cells obviously escape immune surveillance directed to EBV antigens. Previous investigations carried out on EBV\u2010positive Burkitt lymphoma (BL) cells have shown that this fact may be partially accounted for by a lack of expression of ICAM1 (CD54) and LFA3 (CD58). ICAM1 and LFA3 have therefore been investigated in fresh NPC biopsies and transplanted NPCs. With only I exception out of 9 cases, NPC cells appear to express high levels of ICAM I and low levels of LFA3. This is a complete inversion of the pattern observed in normal epithelial cells <jats:italic>in vivo.<\/jats:italic> Additional investigations will be required to determine to what extent these characteristics affect T\u2010cell interactions with NPC cells, specially in the process of EBV\u2010antigen recognition.<\/jats:p>","DOI":"10.1002\/ijc.2910500605","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:39:02Z","timestamp":1171924742000},"page":"863-867","source":"Crossref","is-referenced-by-count":29,"title":["Elevated expression of ICAM1 (CD54) and minimal expression of LFA3 (CD58) in epstein\u2010barr\u2010virus\u2010positive nasopharyngeal carcinoma cells"],"prefix":"10.1002","volume":"50","author":[{"given":"Pierre","family":"Busson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Michel","family":"Guillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher D.","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence S.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Clausse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Lipinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan B.","family":"Rickinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Tursz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910200403"},{"key":"e_1_2_1_3_1","first-page":"188","volume-title":"Tumors of the head and neck. 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