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Forty percent of the tumors were judged as DNA diploid, of which 86% were ER\u2010positive. The proportion of ER\u2010positive tumors among non\u2010diploids was significantly lower, or 73% (<jats:italic>p<\/jats:italic> &lt; 0.001). S\u2010phase fraction (SPF) was estimated in 691 cases (86%), with an overall mean of 8.4%. DNA ploidy as well as ER and PR status were independently related to SPF. Unlike the results obtained in most older series, the biological variables correlated significantly with tumor staging factors such as lymph\u2010node status and tumor size. Patients with nodal involvement, especially those with 4 positive nodes or more, more often had tumors which were receptor\u2010negative, DNA aneuploid and of high S\u2010phase rate. Large tumor size was significantly related to lower frequencies of receptor positivity and strongly related to DNA aneuploidy and high S\u2010phase fraction. Multiple linear regression analysis showed that these relationships were mainly due to the associations of SPF with the other variables. S\u2010phase fraction was the only independent factor predicting nodal status, while DNA ploidy in addition to SPF was associated with tumor size. In fact, DNA ploidy (p &lt; 0.001), ER and PR status (p &lt; 0.001, p = 0.002), nodal status (p = 0.04) and tumor size (p &lt; 0.001) were all independently related to SPF.<\/jats:p>","DOI":"10.1002\/ijc.2910510106","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:38:56Z","timestamp":1171924736000},"page":"28-33","source":"Crossref","is-referenced-by-count":20,"title":["Relationships of DNA ploidy, S\u2010phase fraction and hormone receptor status to tumor stage in breast cancers detected by population screening"],"prefix":"10.1002","volume":"51","author":[{"given":"Olle","family":"St\u00e5l","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Brisfors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Carstensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilianne","family":"Ferraud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hatschek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Nordenskj\u00f6ld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Statistical methods in medical research","author":"Armitage P.","year":"1987"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198903093201003"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1984.2.10.1102"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01806453"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800740221"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880201)61:3<420::AID-CNCR2820610303>3.0.CO;2-0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1980.296"},{"key":"e_1_2_1_9_1","first-page":"29","article-title":"Mammary carcinoma: comparison of DNA content in the primary tumor and the corresponding axillary lymph\u2010node metastases","volume":"94","author":"Erhardt K.","year":"1986","journal-title":"Acta pathol. microbiol. scand. 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