{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:04:27Z","timestamp":1773288267203,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5141,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1992,6,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Epstein\u2010Barr virus (EBV) has been classically associated with nasopharyngeal carcinoma and Burkitt's lymphoma, a monoclonal B\u2010cell non\u2010Hodgkin's lymphoma. Since the EBV genome has also been found in post\u2010transplant lymphomas and lymphomas arising in individuals infected with the human immunodeficiency virus, evidence has now accumulated that EBV might be the initiator of a multi\u2010step process leading from polyclonal B\u2010cell hyperplasias to monoclonal lymphoma. In a retrospective study of 60 T\u2010cell lymphomas of various types, we found EBV DNA in 21 (35%) using Southern\u2010 and\/or dot\u2010blot techniques. Eight of 14 nodal samples of angio\u2010immunoblastic lymphadenopathy (57%) were shown to harbour detectable EBV DNA. The tumour with the next highest frequency, 47% (7\/15 cases analyzed) was pleomorphic T\u2010cell lymphoma, medium\u2010 and large\u2010cell type; EBV was found both in nodal and in extranodal lymphomas of this type. Lymphoepitheloid (Len\u2010nert's) lymphoma and large\u2010cell anaplastic lymphoma were positive in 2\/5 and 3\/8, respectively, of the cases analyzed. No viral DNA could be demonstrated in 3 T\u2010immunoblastic and 5 T\u2010lymphoblastic lymphomas. Clonotypic analysis revealed monoclonal as well as oligoclonal virus populations. Our data suggest that, at least in some of these entities, the presence of the EBV genome might be due to secondary mechanisms such as escape from immune surveillance.<\/jats:p>","DOI":"10.1002\/ijc.2910510410","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:56:19Z","timestamp":1171925779000},"page":"562-567","source":"Crossref","is-referenced-by-count":59,"title":["Prevalence of epstein\u2010barr virus DNA in different T\u2010cell lymphoma entities in a European population"],"prefix":"10.1002","volume":"51","author":[{"given":"German","family":"Ott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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