{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:55:11Z","timestamp":1791312911716,"version":"4.3.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":5101,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1992,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To evaluate the risk of transfusion\u2010related transmission of HTLV\u2010I in Jamaica, a prospective study was initiated, prior to availability of a licensed HTLV\u2010I serological screening assay. This information would prove useful in formulating strategies for blood\u2010donor screening. We followed 118 pre\u2010transfusion HTLV\u2010l\u2010negative transfusion recipients at monthly intervals posttransfusion for I year. Laboratory and questionnaire data were obtained at each visit to evaluate the clinical and immunological status of recipients. Cumulative incidence of HTLV\u2010I seroconversion was estimated and risk\u2010factor data associated with seroconversion among 66 HTLV\u2010l\u2010exposed transfusion recipients were analyzed. Seroconversion occurred in 24\/54 (44%) of recipients of HTLV\u2010l\u2010positive cellular blood components, 0\/12 recipients of positive non\u2010cellular donor units and 0\/52 recipients of HTLV\u2010l\u2010negative donor units. Significant risk factors associated with recipient seroconversion were receipt of a seropositive cellular blood component stored for less than one week [odds ratio (OR) = 6.34, 95% confidence interval (CI) = 1.83 to 21.92], male sex (OR = 4.79, 95% CI = 1.15 to 20.0) or use of immunosuppressive therapy at time of transfusion (OR = 12.20, 95% CI = 0.95 to 156). Risk of blood\u2010borne infection per person per year in Jamaica was estimated to be 0.009%. Our results confirm that blood transfusion carries a significant risk of HTLV\u2010I transmission and that screening of donor blood effectively prevents HTLV\u2010I seroconversion. Recipients at greatest risk for seroconversion were those who required multiple transfusions or who were receiving immunosuppressive therapy at the time of transfusion. These patients should be given priority in receiving selectively screened blood components, if universal blood\u2010donor screening for HTLV\u2010I is not possible.<\/jats:p>","DOI":"10.1002\/ijc.2910510609","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:55:19Z","timestamp":1171907719000},"page":"886-891","source":"Crossref","is-referenced-by-count":189,"title":["A prospective study of transmission by transfusion of HTLV\u2010I and risk factors associated with seroconversion"],"prefix":"10.1002","volume":"51","author":[{"given":"Angela","family":"Manns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainford J.","family":"Wilks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Peter","family":"Figueroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marge","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barrie","family":"Hanchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Blattner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1182\/blood.V74.7.2585.2585","article-title":"Serological confirmation of human T\u2010lymphotropic virus type I infection in healthy blood and plasma donors","volume":"74","author":"Anderson D.","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92774-C"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860815)58:4<903::AID-CNCR2820580417>3.0.CO;2-J"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/oxfordjournals.aje.a115514","article-title":"Sex ratio of human T\u2010lvmphotropic virus type I infection and blood transfusion","volume":"131","author":"Chavance M.","year":"1990","journal-title":"Amer. 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