{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:12Z","timestamp":1786977792871,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5080,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1992,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>During 1984\u201388 a population\u2010based case\u2010control study was carried out in The Netherlands, in collaboration with the International Agency for Research on Cancer, to examine the possible relationship between aspects of medical history and exocrine pancreatic carcinoma in 176 cases and 487 controls. About 58% of patients were interviewed directly. We observed an inverse relationship between medical treatment for allergy\u2010 related conditions and the development of pancreatic cancer (30 cases vs. 130 controls, OR 0.57, 95% Cl 0.36 to 0.90). A history of gallbladder problems, gallstones, cholecystectomy, stomach or duodenal ulcer, pancreatitis, appendicitis, diabetes or tonsillectomy was not related to risk. In direct responses, compared with once daily, a positive relationship was seen for stool frequency, 10 years ago, of less than once daily (18 cases vs. 40 controls, OR 2.10, 95% Cl 1.09 to 4.04). In men, diabetes treated with insulin and diagnosed more than 1 year previously was significantly and positively related to risk (5 cases vs. 1 control, OR 11.66, 95% 1.28 to 105.95). In brief, the results of the present study suggest that a history of allergy\u2010related conditions may protect, whereas a past stool frequency of less than once daily may enhance the risk of cancer of the pancreas. Other elements of the medical history were not consistently related to risk. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910520105","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:52:11Z","timestamp":1171907531000},"page":"17-23","source":"Crossref","is-referenced-by-count":81,"title":["Aspects of medical history and exocrine carcinoma of the pancreas: A population\u2010based case\u2010control study in The Netherlands"],"prefix":"10.1002","volume":"52","author":[{"given":"H. B. Bueno","family":"De Mesquita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Maisonneuve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"Moerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","article-title":"Life\u2010Time history of alcoholic beverages, tea and coffee and exocrine carcinoma of the pancreas: a population\u2010 based case\u2010Control study in The Netherlands","volume":"50","author":"Bueno De Mesquita H. B.","year":"1992","journal-title":"Int. J. Cancer"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910490604"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910480411"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910460319"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/archinte.1968.00300080081016","article-title":"Chronic alcoholism and carcinoma of the pancreas","volume":"122","author":"Burch G. E.","year":"1968","journal-title":"Arch, intern. Med."},{"key":"e_1_2_1_7_1","volume-title":"Deaths by cause of death, age and sex in the year 1989","author":"C. B. S. (cENTRAL BUREAU OF STATISTICS)","year":"1990"},{"key":"e_1_2_1_8_1","first-page":"665","volume-title":"Physiology of the gastrointestinal tract","author":"Christensen J.","year":"1987"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910450504"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850115)55:2<460::AID-CNCR2820550229>3.0.CO;2-V"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00273858"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115129"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910410603"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1985.15"},{"key":"e_1_2_1_15_1","first-page":"333","article-title":"A case\u2010Control study of pancreatic carcinoma in Oklahoma City hospitals, 1970\u20131975. Presentation at the Society of\u2010 Epidemiological Research Meeting, June, 1976","volume":"104","author":"Howson C. P.","year":"1976","journal-title":"Amer. J. Epidemiol."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910470313"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115488"},{"key":"e_1_2_1_18_1","first-page":"673","article-title":"Cancer mortality among diabetics","volume":"44","author":"Kessler I. I.","year":"1970","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711290406"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1001\/jama.1981.03310270027018","article-title":"A multifactorial model for pancreatic cancer in man","volume":"245","author":"Lin R. S.","year":"1981","journal-title":"J. Amer. med. Ass."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(89)90119-4"},{"key":"e_1_2_1_22_1","first-page":"49","article-title":"Pancreas cancer and smoking, beverage consumption, and past medical history","volume":"76","author":"Mack T. M.","year":"1986","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_23_1","first-page":"439","article-title":"Epidemiologic characteristics and trace elements in pancreatic cancer in Greece","volume":"4","author":"Manousos O.","year":"1981","journal-title":"CancerDetec. Prev."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198208263070902"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880615)61:12<2578::AID-CNCR2820611232>3.0.CO;2-0"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1986.185"},{"key":"e_1_2_1_27_1","volume-title":"Statistical Package for Social Sciences \/ PC + Version 3.1","author":"Norusis M. J.","year":"1989"},{"key":"e_1_2_1_28_1","first-page":"181","volume-title":"Physiology of the gastrointestinal tract","author":"Walsh J. H.","year":"1987"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(83)90059-0"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197303)31:3<641::AID-CNCR2820310323>3.0.CO;2-1"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910520105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910520105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T21:45:00Z","timestamp":1695851100000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910520105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,8,19]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,8,19]]}},"alternative-id":["10.1002\/ijc.2910520105"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910520105","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,8,19]]}}}