{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:04Z","timestamp":1760188864180},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5059,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1992,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Histologically diagnosed, or in part questionable, malignant pleomorphic peripheral T\u2010cell lymphomas (pPTCLs, n = 16) and mixed\u2010cellularity Hodgkin's disease (MCHD, n = 12) were objectively compared by the use of combined immunohistochemistry on paraffin sections, test\u2010point analysis of tissue components, and semi\u2010automated nuclear morphometry on semi\u2010thin resin sections. Classical, qualitative histomorphological distinction of these sub\u2010types of lymphomas proved to be valid and is probably still the best method. Quantitative discriminant features, in order of decreasing significance, were: <jats:italic>(i)<\/jats:italic> expression by large atypical cells (LACs) of CD45RO, CD43 and CD45 in pPTCLs, and of CD30 and GD15 in MCHD; <jats:italic>(ii)<\/jats:italic> means and standard deviations (SDs) of LAC nuclear\u2010profile areas (greater in MCHD than in pPTCLs); <jats:italic>(iii)<\/jats:italic> expression of CD3 by LACs in pPTCLs; <jats:italic>(iv)<\/jats:italic> prominence of small lymphoid cells in MCHD; <jats:italic>(v)<\/jats:italic> higher percentage of medium\u2010sized lymphoid cells in pPTCLs; and <jats:italic>(vi)<\/jats:italic> higher SDs of nuclear\u2010profile circularity factor of small lymphoid cells in MCHD. The medians of the largest nucleolar profile areas in LACs per field did not differ in pPTCLs and MCHD, but dispersion of individual values towards higher levels was significantly greater in the latter. Stepwise discriminant analysis of test point and nucleometric variables that best distinguished pPTCLs from MCHD revealed considerable overlaps, and questionable cases tended to be intermediate between the two. In conclusion, our results confirm and expand the notion of intra\u2010group heterogeneity, with indistinct borders and the existence of intermediate phenotypes between these two taxonomic categories of malignant lymphomas. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910520208","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:52:05Z","timestamp":1171925525000},"page":"202-207","source":"Crossref","is-referenced-by-count":6,"title":["Phenotypic overlaps between pleomorphic malignant T\u2010cell lymphomas and mixed\u2010cellularity Hodgkin's disease"],"prefix":"10.1002","volume":"52","author":[{"given":"Piero","family":"Tosi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Leoncini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"del Vecchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatella","family":"Spina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia","family":"Lorenzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Barbini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rita","family":"Massai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Pileri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Sabattini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Kraft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Cottier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7101(91)90063-K"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90148-X"},{"key":"e_1_2_1_4_1","first-page":"953","article-title":"Prognostic value of phenotyping by Ber\u2010H2, Leu\u2010Mi, EMA in Hodgkin's disease","volume":"114","author":"De Mascarel I.","year":"1990","journal-title":"Arch. 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