{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T11:13:50Z","timestamp":1698146030184},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5059,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1992,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have proved that a certain acidic isoform of ferritin is specifically synthesized by the placenta and breast\u2010cancer tissue. In this context it has been further reported that the determination of this so\u2010called placental isoferritin (PLF) on the surface of a subset of peripheral lymphocytes is highly specific and sensitive for early stage breast cancer. By use of the monoclonal antibody CM\u2010H\u20109 and flow cytometry, the levels of placental ferritin (PLF)\u2010positive cells were determined in 133 female patients undergoing surgical excision of a controversial or highly suspicious lesion of the breast detected by mammography. In addition, 61 healthy blood donors served as controls. Values of PLF\u2010positive cells in breast cancer patients differed significantly from those found in women with benign diseases and healthy controls (3.87% vs. 1.55% and 2.02, respectively; p &lt; 0.00001). Analysis of prognostic factors in breast cancer patients (tumor size, lymph\u2010node status, menopausal status, estrogen receptor status, histologic grading and grading subfactors) revealed significantly higher levels of PLF\u2010positive cells in lymph\u2010node\u2010negative patients compared with node\u2010positive patients (p &lt; 0.00001). Furthermore, levels of PLF\u2010positive cells s lowed a significantly negative correlation with tumor size and nuclear polymorphism. In 15 patients who underwent a guidewire\u2010directed surgical biopsy for a non\u2010palpable, mammographically suspect lesion, 4 cases of cancer correlated with high values of PLF\u2010positive lymphocytes while only I patient with a enign histologic result exhibited more than 4% positive cells. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910520213","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:52:05Z","timestamp":1171925525000},"page":"229-233","source":"Crossref","is-referenced-by-count":8,"title":["Determination of placental ferritin (PLF)\u2010positive lymphocytes in women in early stages of breast cancer"],"prefix":"10.1002","volume":"52","author":[{"given":"Harald R.","family":"Rosen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Stierer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"G\u00f6ttlicher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renate","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich","family":"Vogl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Eibl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/242194a0"},{"key":"e_1_2_1_3_1","first-page":"1735","article-title":"Structural and immunological relationships of isoferritins in normal and malignant cells","volume":"36","author":"Arosio P.","year":"1976","journal-title":"Cancer Res."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198605083141905"},{"key":"e_1_2_1_5_1","volume-title":"Breast cancer. 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