{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:44:24Z","timestamp":1792028664352,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5038,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1992,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sixteen human T\u2010cell lines were studied for the expression of a cell\u2010adhesion molecule ICAM\u20101 and its counter\u2010receptor LFA\u20101. The cell lines included 3 human T\u2010cell\u2010leukemia\u2010virus\u2010type\u20101 (HTLV\u20101)\u2010negative cell lines derived from acute lymphoblastic leukemia (ALL) and 13 HTLV\u20101\u2010positive cell lines, 7 of them established from cord\u2010 or peripheral\u2010blood T cells by <jats:italic>in vitro<\/jats:italic> transformation with HTLV\u20101, 2 derived from HTLV\u20101 carriers, and 4 derived from patients with adult T\u2010cell leukemia (ATL). In sharp contrast to a basal level of ICAM\u20101 in 3 HTLV\u20101\u2010negative ALL cell lines, strong induction of ICAM\u20101 was seen in all HTLV\u20101\u2010positive T\u2010cell lines except for MT\u20101, one of the 4 ATL cell lines used in the present study. On the other hand, the expression of LFA\u20101 (CD11a and CD18) was more or less similar among the cell lines with and without HTLV\u20101. Interestingly, however, 3 out of 4 ATL cell lines (TL\u2010Oml, H582, HUT102) revealed striking depression of LFA\u20101 expression. Several lines of evidence strongly argued against direct involvement of the viral transactivator p40<jats:sup>tax<\/jats:sup> or some autocrine cytokines in the induction of ICAM\u20101 in HTLV\u20101\u2010positive T\u2010cell lines. It was also found that ICAM\u20101 and LFA\u20101 were involved in syncytium formation induced in the co\u2010culture of HTLV\u20101\u2010positive and HTLV\u20101\u2010negative human T\u2010cell lines. Implications of constitutive expression of ICAM\u20101 for certain clinical manifestations of ATL and of depression of either ICAM\u20101 or LFA\u20101 during progression of ATL are discussed. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910520316","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:51:25Z","timestamp":1171925485000},"page":"418-427","source":"Crossref","is-referenced-by-count":66,"title":["Strong induction of ICAM\u20101 in human T cells transformed by human T\u2010cell\u2010leukemia virus type 1 and depression of ICAM\u20101 or LFA\u20101 in adult T\u2010cell\u2010leukemia\u2010derived cell lines"],"prefix":"10.1002","volume":"52","author":[{"given":"Kenji","family":"Fukudome","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Furuse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Orita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morio","family":"Nagira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorio","family":"Hinuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Yoshie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.38.020187.001135"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.18.7329"},{"key":"e_1_2_1_4_1","first-page":"487","volume-title":"Leucocyte typing: White\u2010Cell differentiation antigens","author":"Dunlap N. 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