{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:03:09Z","timestamp":1762160589976},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4975,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1992,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of prolonged administration of the gamma\u2010aminobutyric acid receptor agonist muscimol on enhanced induction of gastric carcinogenesis by N\u2010methyl\u2010N\u2032\u2010nitro\u2010N\u2010nitrosoguanid ine (MNNG) in spontaneously hypertensive rats (SHR), and on the norepinephrine concentration in the gastric wall and the labeling index of gastric mucosa were investigated. SHR and normotensive Wistar Kyoto (WKY) rats as controls were given a solution of MNNG (25 fig\/ml) for 25 weeks and then i.p. injections of 0.5 mg\/kg body weight of muscimol every other day. In control WKY rats, gastric cancers were found in I (7%) of 14 rats examined at week 52. In SHR treated with NaCI solution only, the incidence of gastric cancers was significantly increased to 50% compared with that in control WKY rats. However, treatment of SHR with muscimol significantly increased its incidence to 12% compared with the value in SHR treated with NaCI solution only. The norepinephrine concentration in the gastric wall and the labeling index of the gastric mucosa were significantly greater in SHR than in WKY rats. Prolonged administration of muscimol to SHR significantly reduced the norepinephrine concentration in the antral portion of the gastric wall or the labeling index of the antral epithelial cells. These findings indicate that long\u2010term treatment of SHR with muscimol attenuated the enhancement of gastric carcinogenesis in SHR. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910520616","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:47:53Z","timestamp":1171925273000},"page":"924-927","source":"Crossref","is-referenced-by-count":7,"title":["Protection by muscimol against gastric carcinogenesis induced by N\u2010methyl\u2010N\u2032\u2010nitro\u2010N\u2010nitrosoguanidine in spontaneously hypertensive rats"],"prefix":"10.1002","volume":"52","author":[{"given":"Masaharu","family":"Tatsuta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Iishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyako","family":"Baba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Nakaizumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruo","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01393362"},{"key":"e_1_2_1_3_1","first-page":"259","article-title":"Nicotine influence upon the development of experimental stomach tumors","volume":"4","author":"Gurkalo V. 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