{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:31:26Z","timestamp":1778049086623,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4925,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1993,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A population\u2010based case\u2010control study of kidney cancer was carried out in New South Wales using data from structured interviews with 489 cases of renal\u2010cell cancer and 147 cases of renal pelvic cancer diagnosed in 1989 and 1990, together with 523 controls from the electoral rolls. This study showed that the risk of renal pelvic cancer was increased by phenacetin\/aspirin compound analgesics (RR = 12.2; 95% CI 6.8\u201022.2) to a far greater extent than by paracetamol (RR = 1.3; 95% CI 0.7\u20102.4; not significant). There was a doubling of risk (RR = 2.0; 95% CI 0.94.4) in the highest tertile of paracetamol taken in any form compared with values for non\u2010users of any type of analgesic. By contrast, the risk of renal\u2010cell cancer appeared to be increased to a similar degree by phenacetin\/aspirin compound analgesics (RR = 1.4; 95% CI 0.9\u20102.3) and paracetamol taken in any form (RR = 1.5; 95% CI 1.0\u20102.3). When both drugs were treated as alternative forms of the same risk factor, the risk was increased by 1.7 (95% CI 1.2\u20102.4). On this evidence, we postulate that phenacetin\/aspirin compounds are weakly carcinogenic in the renal parenchyma through the metabolic conversion of phenacetin to paracetamol, and potently carcinogenic in the renal pelvis by different or additional pathways involving renal papillary necrosis. In addition, there is an indication of a weak link between paracetamol and renal pelvic cancer.<\/jats:p>","DOI":"10.1002\/ijc.2910530212","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:27:34Z","timestamp":1171927654000},"page":"245-249","source":"Crossref","is-referenced-by-count":75,"title":["Different roles for phenacetin and paracetamol in cancer of the kidney and renal pelvis"],"prefix":"10.1002","volume":"53","author":[{"given":"Margaret","family":"McCredie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. E.","family":"Day","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"373","article-title":"The influence of phenacetin or mechanical perforation on the development of renal pelvic and urinary bladder tumors in FANFT\u2010induced urinary tract carcinogenesis","volume":"91","author":"Anderstr\u00f6m C.","year":"1983","journal-title":"Acta pathol. microbiol. immunol. scand., A"},{"key":"e_1_2_1_3_1","volume-title":"The analysis of case\u2010control studies","author":"Breslow N. E.","year":"1980"},{"key":"e_1_2_1_4_1","first-page":"37","article-title":"Reactive metabolites of phenacetin and acetaminophen: a review","volume":"50","author":"Hinson J. A.","year":"1983","journal-title":"Environ. Hlth. Persp."},{"key":"e_1_2_1_5_1","series-title":"Updating of IARC Monographs","first-page":"310","volume-title":"LARC Monographs on the evaluation of carcinogenic risks to humans","author":"International Agency FOR Research ON Cancer","year":"1987"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910440603"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199011000-00004"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(91)90149-8"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910420104"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000185079"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(92)90254-Y"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00146885"},{"key":"e_1_2_1_13_1","unstructured":"McCredie M.andStewart J. H. Risk factors for kidney cancer in New South Wales: IV. Occupation. Brit. J. indust. Med. (1992c) (In press)."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1986.154"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)50936-2"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1983.tb06561.x"},{"key":"e_1_2_1_17_1","first-page":"134","article-title":"Is phenacetin responsible for analgesic nephropathy in New South Wiles?","volume":"17","author":"McCredie M.","year":"1982","journal-title":"Clin. Nephrol."},{"key":"e_1_2_1_18_1","first-page":"35","article-title":"The effect of withdrawal of phenacetin\u2010containing analgesics on the incidence of kidney and urothelial cancer and renal failure","volume":"31","author":"McCredie M.","year":"1989","journal-title":"Clin. Nephrol."},{"key":"e_1_2_1_19_1","first-page":"287","article-title":"Etiology of cancer of the renal pelvis.","volume":"71","author":"McLaughlin J. K.","year":"1983","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_20_1","first-page":"275","article-title":"A population\u2010based case\u2010control study of renal cell carcinoma.","volume":"72","author":"McLaughlin J. K.","year":"1984","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6710.1247"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198223010-00004"},{"key":"e_1_2_1_23_1","first-page":"1045","article-title":"Analgesics, cigarette smoking, and other risk factors for cancer of the renal pelvis and ureter","volume":"49","author":"Ross R. K.","year":"1989","journal-title":"Cancer Res."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000185116"},{"key":"e_1_2_1_25_1","volume-title":"Epidemiological Graphics, Estimation and Testing software (EGRET)","author":"Statistics AND Epidemiology Research Corporation","year":"1990"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910530212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910530212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:19:21Z","timestamp":1695878361000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910530212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1,21]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,1,21]]}},"alternative-id":["10.1002\/ijc.2910530212"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910530212","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1,21]]}}}