{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:23:43Z","timestamp":1792146223494,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4875,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1993,3,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thrombocytosis and fever are frequent symptoms in children with hepatoblastoma. Interleukin\u20106 (IL\u20106) has been shown to mediate thrombocytosis and an acute\u2010phase reaction including fever. We therefore investigated samples from I4 untreated patients with hepatoblastoma for this cytokine and in addition for interleukin\u2010I \u03b1 (IL\u2010I\u03b1), interleukin\u2010I\u03b2 (IL\u2010I\u03b2) and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), all of which are known to induce IL\u20106 production. High serum levels of IL\u20106 were only found in 3\/I4 patients; the other cytokines were not detectable. In contrast, I2\/I4 tumors produced substantial amounts of IL\u20106 in primary cell culture, while IL\u2010I\u03b2 was found in 3\/I4 supernatants; IL\u2010I\u03b1 and TNF\u2010\u03b1 were always negative. Immunoenzymatic staining of fresh tumors revealed that IL\u20106 is not produced by the tumor cells, but rather by surrounding fibroblasts and endothelial cells. In tumor cells only IL\u2010I\u03b2, but neither IL\u2010I\u03b1, TNF\u2010\u03b1 nor IL\u20106, could be detected. In co\u2010culture experiments with fibroblasts and endothelial cells, addition of hepatoblastoma cells enhanced IL\u20106 production. Including an IL\u2010I receptor antagonist abolished this effect incompletely. Our results suggest that tumor cells in hepatoblastoma induce IL\u20106 production in surrounding fibroblasts and endothelial cells by virtue of their endogenous secretion of IL\u2010I\u03b2 and supposedly some other, as yet unidentified, mediator.<\/jats:p>","DOI":"10.1002\/ijc.2910530504","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:16:06Z","timestamp":1171926966000},"page":"728-734","source":"Crossref","is-referenced-by-count":29,"title":["Production of interleukin\u20101\u03b2 and interleukin\u20106 in hepatoblastoma"],"prefix":"10.1002","volume":"53","author":[{"given":"Dietrich Von","family":"Schweinitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin R.","family":"Hadam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Welte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Mildenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Pietsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80219-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1182\/blood.V75.8.1602.1602","volume":"75","author":"Asano S.","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)80766-X"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/32.2.6198355"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.147.4.1261"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/343336a0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830181010"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1967)20:3<396::AID-CNCR2820200308>3.0.CO;2-O"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1182\/blood.V74.4.1241.1241","article-title":"Interleukin 6 is a potent thrombopoietic factor in mice","volume":"74","author":"Ishibashi T.","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.15.5953"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-96889-1_24"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"l","DOI":"10.1182\/blood.V74.1.1.1","article-title":"The biology of interleukin\u20106","volume":"74","author":"Kishimoto T.","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_14_1","first-page":"688","article-title":"Recombinant human interleukin 6 is a potent inducer of the acute phase response and elevates the blood platelets in nonhuman primates","volume":"19","author":"Mayer P.","year":"1991","journal-title":"Exp. 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