{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T13:11:08Z","timestamp":1698412268448},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T00:00:00Z","timestamp":1255392000000},"content-version":"vor","delay-in-days":6039,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epstein\u2010Barr virus (EBV)\u2010carrying Burkitt lymphoma (BL) lines which maintain the phenotypic characteristics of the <jats:italic>in vivo<\/jats:italic> tumor cells are more sensitive to natural (NK), interferonactivated (IAK) and IL\u20102\u2010activated (LAK) cytotoxicity than EBV\u2010immortalized lymphoblastoid cell lines (LCL) of normal B\u2010cell origin. All BL cells carry chromosomal translocations which lead to deregulated expression of the c\u2010myc oncogene. LCLs transfected with constitutively active c\u2010myc alleles display changes in growth properties and surface phenotype. In this study, we have examined the effect of c\u2010myc deregulation on the sensitivity of LCLs to NK, IAK and LAK effectors. C\u2010myctransfected LCLs showed an increased sensitivity to lysis which correlated with the level of c\u2010myc expression. Expression of HLA class I and sensitivity to allospecific and EBV\u2010specific cytotoxic T\u2010lymphocytes (CTL) remained unchanged. Transfection of a constitutively active v\u2010H\u2010ras gene, which also induces changes in growth properties and cell\u2010surface phenotype, did not alter the sensitivity of LCLs to NK or LAK cytotoxicity.<\/jats:p>","DOI":"10.1002\/ijc.2910530625","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T18:20:59Z","timestamp":1278526859000},"page":"1008-1012","source":"Crossref","is-referenced-by-count":3,"title":["Over\u2010expression of c\u2010<i>myc<\/i> increases the sensitivity of epstein\u2010barr virus immortalized lymphoblastoid cells to non\u2010MHC\u2010restricted cytotoxicity"],"prefix":"10.1002","volume":"53","author":[{"given":"Laura","family":"Cuomo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quian\u2010Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigurbj\u00f6rg","family":"Torsteinsdottir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria G.","family":"Masucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigia","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Dalla\u2010Favera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,13]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/341159a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90296-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1982.tb00342.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7025208"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910450332"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2237417"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.4049\/jimmunol.138.11.3996","article-title":"Enhancer lytic susceptibility of H\u2010ras transformants after oncogene induction is specific to activated killer cells","volume":"138","author":"Johnson P. 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