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To study the effects of deregulated c\u2010myc expression on T\u2010cell development and oncogenesis, we sought to generate a transgenic mouse model in which c\u2010myc expression was targeted specifically to the T\u2010cell lineage. A plasmid construct containing a dominant control region (DCR) from the human CD2 locus linked 5\u2032 to the human c\u2010myc gene was used to generate 2 lines of transgenic mice. Both strains developed thymic lymphoma at low frequency, but thymic development and peripheral T\u2010cell numbers were otherwise apparently normal. Low tumour penetrance was consistent with the observed lack of stable CD2\u2010myc transgene mRNA in tissues of healthy transgenic mice. In contrast, transgene RNA was detected in all malignant tumours as well as in early lymphomatous lesions. RNase protection analyses confirmed these findings and showed that the PI human c\u2010myc promoter was active in all neoplastic tissues but not in the thymus or other tissues of healthy transgenic mice. Despite the low spontaneous tumour incidence, the presence of the transgene markedly and uniformly accelerated the onset of tumours after neonatal infection with Moloney murine leukaemia virus. All tumours were rearranged for T\u2010cell receptor f3\u2010chain genes and were of T\u2010cell origin from their surface phenotype (Thy\u2010I +. CD3+, CD4+\/\u2010, CDB+, slg\u2010). Virus\u2010accelerated tumours contained clonal integrations of Moloney murine leukaemia virus, suggesting that proviral insertional mutagenesis may have played a role in tumour development. Analysis of several candidate myccooperating genes failed to reveal any rearrangements apart from a low frequency involving proviral insertion at the pim\u2010I locus. The CD2\u2010myc mouse should therefore be a valuable system in screening for novel myc\u2010collaborating genes involved in T\u2010cell lymphoma.<\/jats:p>","DOI":"10.1002\/ijc.2910530628","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T18:20:06Z","timestamp":1278526806000},"page":"1023-1030","source":"Crossref","is-referenced-by-count":42,"title":["Conditional expression and oncogenicity of c\u2010<i>myc<\/i> linked to a CD2 gene dominant control region"],"prefix":"10.1002","volume":"53","author":[{"given":"M.","family":"Stewart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"McFarlane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Toth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Onions","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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