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In addition to small non\u2010cleaved\u2010cell (SNCC) and large\u2010cell immunoblastic (LCI) non\u2010Hodgkin's lymphomas (NHLs), a relatively high occurrence of anaplastic large\u2010cell Ki\u20101\u2010positive (ALC Ki\u20101<jats:sup>+<\/jats:sup>) lymphomas and Hodgkin's disease (HD) was observed, at variance with other reported series of HIV<jats:sup>+<\/jats:sup> patients. Combined results of <jats:italic>in situ<\/jats:italic> hybridization and Southern\u2010blot analyses, in conjunction with immunohisto\u2010chemical detection of Epstein\u2010Barr virus (EBV)\u2010encoded latent membrane protein\u20101 (LMP\u20101), showed an almost complete association of ALC Ki\u20101<jats:sup>+<\/jats:sup> lymphomas and HD cases with EBV. The neoplastic cells of both these LMs also showed common immunophenotypic features such as frequent absence of B\u2010 and T\u2010cell differentiation markers and expression of the Ki\u20101 activation marker, while SNCC and LCI lymphomas were mainly of mature B\u2010cell origin and Ki\u20101<jats:sup>\u2010<\/jats:sup>. The concomitant high incidence of ALC Ki\u20101<jats:sup>+<\/jats:sup> lymphomas and HD in a specific group of HIV<jats:sup>+<\/jats:sup> patients, their almost complete association with EBV in clonal and episomal form and the great similarity in differentiation, activation and virological markers which they display suggest that these LMs are pathological variants of a continuous spectrum of HIV\u20101\u2010associated disorders etiopathologically linked to EBV.<\/jats:p>","DOI":"10.1002\/ijc.2910540110","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:09:49Z","timestamp":1171926589000},"page":"53-59","source":"Crossref","is-referenced-by-count":36,"title":["High incidence of monoclonal EBV episomes in Hodgkin's disease and anaplastic large\u2010cell ki\u20101\u2010positive lymphomas in HIV\u20101\u2010positive patients"],"prefix":"10.1002","volume":"54","author":[{"given":"Mauro","family":"Boiocchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valli","family":"De Re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Doixetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Marzorro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annunziata","family":"Gloghini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanucla","family":"Vaccher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Bertola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198804000-00002"},{"key":"e_1_2_1_3_1","first-page":"1035","article-title":"Detection of Epstein\u2010Barr virus by in situ hybridization. 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