{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:41:36Z","timestamp":1789940496327,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4818,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1993,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two distinct diseases, adult T\u2010cell leukemia (ATL) and HTLV\u20101\u2010associated myelopathy\/tropical spastic paraparesis (HAM\/TSP), develop in a minor population of HTLV\u20101 carriers. We examined the relationship between the viral genome dose in the peripheral\u2010blood mononuclear cells and the serological response in HTLV\u20101 carriers and patients with HAM\/TSP. The antibody titer to HTLV\u20101 gag and env proteins, as well as the frequency of an antibody response to viral protein p40<jats:sup>tax<\/jats:sup> and the titer, increased with increasing viral genome dose. However, the number of abnormal lymphocytes was not directly related to the host viral load. Patients with HAM\/TSP generally showed a higher genome dose than healthy carriers and also had higher antibody titers than healthy carriers with the same HTLV\u20101 load, supporting the existence of an augmented immune response in these patients. These findings suggest that the antibody titer to HTLV\u20101 genome products, and not the number of abnormal lymphocytes, intimately reflects the approximate viral load in HTLV\u2010I \u2010infected individuals.<\/jats:p>","DOI":"10.1002\/ijc.2910540208","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:09:33Z","timestamp":1171926573000},"page":"208-212","source":"Crossref","is-referenced-by-count":29,"title":["Relationship between the anti\u2010HTLV\u20101 antibody level, the number of abnormal lymphocytes and the viral\u2010genome dose in HTLV\u20101\u2010infected individuals"],"prefix":"10.1002","volume":"54","author":[{"given":"Osamu","family":"Shinzato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shiku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimeru","family":"Kamihira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayoshi","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takcnao","family":"Kanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.4.1182"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.22.8526"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1182\/blood.V75.2.428.428","article-title":"High human T\u2010cell\u2010lymphotropic\u2010virus type\u20101 proviral DNA load with polyclonal integration in peripheral\u2010blood mononuclear cells of French West Indian, Guianese and African patients with tropical spastic paraparesis","volume":"75","author":"Gessain A.","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_6_1","first-page":"1156","article-title":"HTLV\u20101 carrier mothers with high\u2010titer antibody are at high risk as a source of infection","volume":"78","author":"Hino S.","year":"1987","journal-title":"Jap. 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