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The T\u2010cell\u2010targeting immunosuppressants, FK506 and cyclosporin A (CsA), suppressed proliferation of the HAM\/TSP\u2010derived T\u2010cell lines, H89\u201359, H89\u201379 and H109. FK506 and CsA also reduced expression of the proto\u2010oncogenes, c\u2010myc and c\u2010fos, but not c\u2010jun and interleukin\u20102\u2010receptor\u2010\u03b1 (IL\u20102R\u03b1) gene in H109 cells. The growth\u2010inhibitory effects of FKS06 and CsA were not abrogated by interleukin 2 (IL\u20102). These results suggest that the inhibitory effects of FK506 and CsA are independent of IL\u20102, and are associated with the reduction of c\u2010myc and c\u2010fos gene expression.<\/jats:p>","DOI":"10.1002\/ijc.2910540230","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:09:33Z","timestamp":1171926573000},"page":"348-354","source":"Crossref","is-referenced-by-count":10,"title":["FK506 and cyclosporin a regulate proliferation and proto\u2010oncogene expression in HTLV\u20101 \u2010associated myelopathy\/tropical\u2010spastic\u2010paraparesis\u2010derived T cells"],"prefix":"10.1002","volume":"54","author":[{"given":"Toshiki","family":"Natazuka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyo","family":"Umemiya\u2010Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimitsu","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Saida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/332166a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90534-2"},{"key":"e_1_2_1_4_1","first-page":"2821","article-title":"Anti\u2010proliferative effect of FK506 and cyclosporine on adult human hepatocytes in culture","volume":"23","author":"Blanc P.","year":"1991","journal-title":"Transplant. 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