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Amplification was found more frequently in estrogen\u2010 and progesterone\u2010receptor\u2010positive tumors and in tumors with high lymph\u2010node involvement. Breast tumor samples were also analyzed for the amplification of <jats:italic>fgfr<\/jats:italic>3 and erbB2 genes and the chromosome I Iq 13 located genes <jats:italic>hst<\/jats:italic> I <jats:italic>Iint<\/jats:italic>2<jats:italic>lbci<\/jats:italic>1 <jats:italic>\/sea<\/jats:italic>. erbB2 gene was amplified 2\u2010 to 13\u2010fold in 13% of the cases, but no amplification of int2\/hst I\/be\/1\/sea amplicon was found. Gynecological tumors were also analyzed for the amplification of <jats:italic>fgfr<\/jats:italic>4 and <jats:italic>fgfr<\/jats:italic>3 genes and for <jats:italic>int2<\/jats:italic> and hst I oncogenes. Eleven of the 15 gynecological tumors were ovarian neoplasms including 2 benign tumors; the remainder comprised I ovarian metastasis of breast cancer; I endometrial cancer; I uterine leiomyosarcoma and I carcinosarcoma of the fallopian tube. In gynecological tumors, <jats:italic>fgfr<\/jats:italic>4 gene was found to be amplified in 2 ovarian tumors. Amplification of <jats:italic>hst<\/jats:italic> I was found in I benign ovarian tumor. Thus, the <jats:italic>fgfr<\/jats:italic>4 gene may be involved in breast and ovarian tumorigenesis.<\/jats:p>","DOI":"10.1002\/ijc.2910540305","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:09:28Z","timestamp":1171926568000},"page":"378-382","source":"Crossref","is-referenced-by-count":117,"title":["Amplification of <i>fgfr<\/i>4 gene in human breast and gynecological cancers"],"prefix":"10.1002","volume":"54","author":[{"given":"Susanna","family":"Jaakkola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Salmikangas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Nylund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pentti","family":"Lehtovirta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heli","family":"Nevanlinna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Partanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Pyrh\u00f6nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"413","article-title":"Chromosomal localization of the hst oncogene and its co\u2010amplification with the int2 oncogene in human melanoma","volume":"2","author":"Adelaide J.","year":"1988","journal-title":"Oncogene"},{"key":"e_1_2_1_3_1","first-page":"659","article-title":"BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers","volume":"6","author":"Adnane J.","year":"1991","journal-title":"Oncogene"},{"key":"e_1_2_1_4_1","first-page":"89","article-title":"The amplification unit on chromosome 11q13 in aggressive primary human breast tumors entails the bcl\u20101, int\u20102 and hst loci","volume":"4","author":"Ali I. 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