{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:09:39Z","timestamp":1761487779701},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":4777,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1993,6,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult T\u2010cell\u2010leukemia (ATL) cells were examined for suscep tibility to human T\u2010cell\u2010leukemia virus type I (HTLV\u2010I) tax\u2010specific cytotoxic T lymphocytes (CTL) derived from a patient with HTLV\u2010l\u2010associated myelopathy\/tropical spastic parapare sis (HAM\/TSP). These CTL efficiently killed HLA\u2010matched leukemia cells of an ATL patient after overnight incubation. However, ATL cells immediately after isolation from the periph eral blood were only marginally susceptible to the CTL. This is not due to inappropriate expression of major\u2010histocompatibility\u2010complex(MHC)\u2010class\u2010l antigen on the leukemia cells. Addition of synthetic peptide, corresponding to the CTL epitope, to the assay enabled the CTL to kill the fresh ATL cells. Scarcity of HTLV\u2010I antigens in the fresh ATL cells and induction of these antigens by in vitro incubation were demonstrated both on the cell surface and in the cytoplasm. Lectin stimulation augmented synthesis of HTLV\u2010I antigens, but was not essential for the induction. The presence in the culture of human plasma contain ing a high titer of antibodies to HTLV\u2010I did not affect the induction of HTLV\u2010I expression in the ATL cells. Furthermore, significantly lower levels of HTLV\u2010I tax mRNA were present in the fresh ATL cells than in the cultured ATL cells, whereas the levels of HTLV\u2010I proviral <jats:italic>tax<\/jats:italic> gene did not differ among these cells. This suppression of HTLV\u2010I transcription in fresh ATL cells accounts for resistance to the CTL, and could be a reason for the persistence of HTLV\u2010I infection <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910540411","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:09:27Z","timestamp":1171926567000},"page":"582-588","source":"Crossref","is-referenced-by-count":51,"title":["Expression of the target antigen for cytotoxic T lymphocytes on adult T\u2010cell\u2010leukemia cells"],"prefix":"10.1002","volume":"54","author":[{"given":"Mari","family":"Kannagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzo","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830160413"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2992082"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6276975"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.22.8526"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1182\/blood.V80.4.1012.1012","article-title":"Frequent clonal proliferation of human T\u2010cell\u2010leukemia\u2010virus\u2010type\u20101(HTLV\u2010I)\u2010infected T cells in HTLV\u2010I\u2010associated myelopathy (HAM\/TSP)","volume":"80","author":"Furukawa Y.","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199009053523"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1128\/jvi.65.3.1628-1633.1991","article-title":"Human T\u2010cell\u2010leukemia\u2010virus\u2010type\u2010I(HTLV\u2010I) expression in fresh pe ripheral\u2010blood mononuclear cells from patients with tropical spastic paraparesis\/HTLV\u2010I\u2010associated myelopathy","volume":"65","author":"Gessain A.","year":"1991","journal-title":"J. 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