{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T08:10:38Z","timestamp":1698307838839},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4715,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1993,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was aimed at comparing screen\u2010detected and symptomatic breast carcinomas with regard to the prevalence of positive immunostaining for c\u2010erb\u2010B\u20102 oncoprotein. Paraffin sections of 81 breast carcinomas detected through the National Screening Programme were examined for the over\u2010expression of c\u2010erbB\u20102 oncoprotein using the avidin\u2010biotin immunoperoxidase technique and 2 different specific antibodies: 21N and 4D5. Twenty\u2010one other carcinomas detected in symptomatic patients were similarly examined for comparison. The screen\u2010detected lesions were of 2 types: palpable and impalpable which required needle localization prior to surgical removal. Of the 81 screen\u2010detected tumours, only 8 were c\u2010erbB\u20102 positive, compared with 5 out of 21 non\u2010screen\u2010detected tumours. When only invasive carcinomas were considered, 5 out of 63 screen\u2010detected cases were positive, compared with 5 out of 15 symptomatic cases. Four out of the 5 screen\u2010detected positive invasive carcinomas were clinically palpable. Our results show an obvious trend towards a lower prevalence of c\u2010erbB\u20102 oncoprotein over\u2010expression in screen\u2010detected carcinomas. As this over\u2010expression is thought to be associated with increased tumour aggressiveness, the findings suggest a low prevalence of aggressive tumours in screen\u2010detected lesions, particularly impalpable invasive carcinomas, identified so far. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910550112","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:50:20Z","timestamp":1171929020000},"page":"63-65","source":"Crossref","is-referenced-by-count":2,"title":["C\u2010erbB\u20102 oncoprotein in screen\u2010detected breast carcinoma: An immunohistological study"],"prefix":"10.1002","volume":"55","author":[{"given":"Salma","family":"Soomro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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