{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:00:51Z","timestamp":1791046851217,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4715,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1993,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The expression of mucin carbohydrates [Tn, sialosyl\u2010Tn(STn), and T antigens] and core proteins [MUCI\u2010apomucin\u2010related antigen (ARA) and MUC2\u2010ARA] was examined immunohisto\u2010chemically in tissues from 40 patients with hepatolithiasis and 26 patients with intrahepatic bile\u2010duct carcinoma. Tn and STn antigens were expressed in most of the carcinomas, and were also often expressed in the atypical bile\u2010duct epithelium of the patients with hepatolithiasis or carcinoma, whereas they were rarely or never expressed in the normal bile duct, suggesting that they are effective tumor markers. T antigen was less useful as a marker for intrahepatic bile\u2010duct carcinoma or the atypical epithelium, because it was expressed in normal bile\u2010duct of some cases. Regarding the expression of ARAs in the carcinomas, non\u2010invasive bile\u2010duct cyst adenocarcinomas with favorable prognosis either expressed no MUCI\u2010ARA with [DF3(\u2010), MUSE11(\u2010) and 139H2(\u2010)] staining pattern or expressed MUCI\u2010ARA with [DF3(\u2010), MUSE11(+) and 139H2(+)] staining pattern. However these tumors often expressed MUC2\u2010ARA with [anti\u2010MRP(+) and CCP58(+)] staining pattern. In contrast, most invasive non\u2010papillary cholangiocarcinomas with poor prognosis expressed MUCI\u2010ARA with [DF3( + ), MUSE 11(+) and 139H2(+)] staining pattern, but expressed no MUC2\u2010ARA with [anti\u2010MRP(\u2010) and CCP58(\u2010)] staining pattern. These results suggests that different apomucins are produced by bile\u2010duct cystadenocarcinomas and cholangiocarcinomas with differing prognosis. Furthermore, expression of Tn and STn antigens is a useful indicator of malignancy in the intrahepatic duct. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910550116","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:50:20Z","timestamp":1171929020000},"page":"82-91","source":"Crossref","is-referenced-by-count":79,"title":["Immunohistochemical study of mucin carbohydrates and core proteins in hepatolithiasis and cholangiocarcinoma"],"prefix":"10.1002","volume":"55","author":[{"given":"Kaneteru","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Yonezawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadao","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shirahama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koro","family":"Sakoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohzoh","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Xiang","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian F. 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