{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:31:24Z","timestamp":1780590684939,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4652,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1993,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic infection with hepatitis\u2010B virus (HBV) is associated with high risk for the development of hepatocellular carcinoma (HCC). Several studies have implicated that the X gene product(s) of HBV are important to the pathogenesis of HCC. This study tests the hypothesis that immunohistochemical detection of hepatitis B x antigen (HBxAg) is closely associated with HCC. The patterns of HBxAg were determined by staining in tumor and non\u2010tumor liver sections from 30 Chinese patients with HBV\u2010associated HCC, and the results were compared with other markers of infection. HBxAg was the most prevalent marker of HBV infection both in tumor and in non\u2010tumor tissues of HCC patients, as compared with the hepatitis\u2010B surface and core antigens. This pattern was observed among carriers as well as several patients who were HBsAG in serum. The HBxAg staining results were validated by Southern blotting with an X\u2010region probe and by Western blotting with anti\u2010HBx. These results suggest that the persistence of HBxAg is important to the pathogenesis of early HCC and that HBxAg expression in the liver during chronic HBV infection may be an important prognostic marker for the development of HCC.<\/jats:p>","DOI":"10.1002\/ijc.2910550409","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:44:15Z","timestamp":1171928655000},"page":"571-576","source":"Crossref","is-referenced-by-count":35,"title":["The value of hepatitis B x antigen as a prognostic marker in the development of hepatocellular carcinoma"],"prefix":"10.1002","volume":"55","author":[{"given":"Minghua","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Thomas","family":"London","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Xun","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Feitelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"209","volume-title":"Viral hepatitis and liver disease","author":"Beasley R. 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