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The cell adhesion molecule, ICAM\u20101, has been shown to be inducible by interleukin\u20101 (IL\u20101). Furthermore, ICAM\u20101 may be involved in the progression of metastasis in certain malignancies. The aim of this study was to measure intracystic soluble ICAM\u20101 (sICAMu\u2010l) and IL\u20101 \u03b1\/\u03b2 levels and to assess the relationships between these substances. Wide\u2010ranging concentrations of sICAM\u20101, IL\u20101\u03b1 and IL\u20101\u03b2 were found in breast\u2010cyst fluid. The high\u2010electrolyte\u2010ratio group had intracystic levels of sICAM\u20101 and IL\u20101\u03b2 which were significantly higher than those of the low\u2010electrolyte\u2010ratio group. No significant difference was found between IL\u20101\u03b1 concentrations in the 2 groups of breast cysts. Strong positive correlations were found between sICAM\u20101 and IL\u20101\u03b1, sICAM\u20101 and IL\u20101\u03b2, and IL\u20101\u03b1 and IL\u20101\u03b2. The significance of the higher concentrations of sICAM\u20101 in the high\u2010electrolyte\u2010ratio group remains to be determined, but the results of this study suggest that sICAM\u20101 levels in the high\u2010electrolyte\u2010ratio group may be regulated in part by IL\u20101\u03b1 and IL\u20101\u03b2.<\/jats:p>","DOI":"10.1002\/ijc.2910550412","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:44:15Z","timestamp":1171928655000},"page":"586-589","source":"Crossref","is-referenced-by-count":5,"title":["Possible regulation of soluble icam\u20101 levels by interleukin\u20101 in a sub\u2010set of breast cysts"],"prefix":"10.1002","volume":"55","author":[{"given":"L. 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