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Ascertainment of <jats:italic>H. pylori<\/jats:italic> status was based on the presence of specific IgG to <jats:italic>H. pylori<\/jats:italic>. For the entire group, an association of this infection with gastric adenocarcinoma was suggested but not statistically significant. For patients in a putatively high\u2010risk subgroup (non\u2010cardia tumors and age \u226470 years), the association was significant. Assays detecting serum IgA to whole <jats:italic>H. pylori<\/jats:italic> cells and cytotoxin, IgG to cytotoxin and Hp54K (the heat\u2010shock protein homolog) and serum neutralization of cytotoxin activity each showed clear differences between <jats:italic>H. pylori\u2010infected<\/jats:italic> and uninfected persons in this population. However, for none of these assays was there a significant difference between values for <jats:italic>H. pylori\u2010infected<\/jats:italic> persons with or without gastric cancer. Thus, while <jats:italic>H. pylori<\/jats:italic> infection was associated with non\u2010cardia gastric cancer in Japanese persons \u226470 years of age, use of these additional serologic markers did not define additional factors that might be associated with increased risk.<\/jats:p>","DOI":"10.1002\/ijc.2910550518","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:39:06Z","timestamp":1171928346000},"page":"799-802","source":"Crossref","is-referenced-by-count":52,"title":["<i>Helicobacter pylori<\/i> infection in japanese patients with adenocarcinoma of the stomach"],"prefix":"10.1002","volume":"55","author":[{"given":"Martin J.","family":"Blaser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Cover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene D.","family":"Feurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo I.","family":"P\u00e9rez\u2010p\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90156-S"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.4.626"},{"key":"e_1_2_1_4_1","series-title":"IARC scientific publications 32","first-page":"164","volume-title":"Statistical methods in cancer research. 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