{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T21:30:19Z","timestamp":1696195819275},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4549,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have shown that embryonic stem cells (ES) may participate in normal embryonic development when they are injected into the blastocyst. In contrast, ES cells develop into tumors if injected in ectopic sites in adult mice. In this study we injected ES\u2010D3 cells, with the <jats:italic>Lac<\/jats:italic>Z gene incorporated, into 5\u2010day pregnant mouse uteri, into pregnant unilaterally salpingectomized uteri, into pseudo pregnant uteri and into non\u2010pregnant uteri. X\u2010gal staining enabled us to identify injected ES cells on the 7th, 9th, 10th, 12th and 15th days post\u2010injection. In pregnant decidua, the ES cells were located initially in the mesometrial decidua and later distributed in the basal and capsular decidua and in the endodermic layer of the visceral yolk sac. In pregnant, unilaterally salpingectomized mouse uteri, ES cells were mainly located in the uterine lumen and tumors were not observed in either case. In contrast, ES cells injected into pseudopregnant uteri often developed into tumors and those injected into non\u2010pregnant uteri always developed into teratocarcinomas. We conclude that the pregnant\u2010uterine microenvironment may participate in the control of ES cell growth.<\/jats:p>","DOI":"10.1002\/ijc.2910560317","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:38:50Z","timestamp":1171928330000},"page":"387-392","source":"Crossref","is-referenced-by-count":7,"title":["Growth control of embryonic stem cells injected into mouse uterus on fifth day of pregnancy"],"prefix":"10.1002","volume":"56","author":[{"given":"M.","family":"Monzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"de Anta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Peris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Ruano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1242\/dev.105.4.733","article-title":"An assessment of the development potential of embryonic stem cells in mid\u2010gestation mouse embryo","volume":"105","author":"Beddington R. S. P.","year":"1989","journal-title":"Development"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/309255a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.4.1049"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001250102"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/292154a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296381"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/299063a0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041480207"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000292668"},{"key":"e_1_2_1_11_1","first-page":"66","volume-title":"The early conceptus, normal and abnormal","author":"Kirby D. R. S.","year":"1965"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091720110"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(92)90065-R"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.12.7634"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.9.3585"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5589-2_9"},{"key":"e_1_2_1_17_1","first-page":"3987","article-title":"Trophectoderm in control of murine embryonal carcinoma","volume":"44","author":"Pierce G. B.","year":"1984","journal-title":"Cancer Res."},{"key":"e_1_2_1_18_1","first-page":"67","volume-title":"Cellular endocrinology: hormonal control of embryonic and cellular differentiation","author":"Pierce G. B.","year":"1986"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.12.6649"},{"key":"e_1_2_1_20_1","first-page":"1996","article-title":"Tumors as caricatures of the process of tissue renewal: prospects for therapy directing differentiation","volume":"48","author":"Pierce G. B.","year":"1988","journal-title":"Cancer Res."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.23.7608"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(90)90138-H"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(91)90120-R"},{"key":"e_1_2_1_24_1","first-page":"23","volume-title":"Teratocarcinoma stem cells","author":"Stevens L. C.","year":"1983"},{"key":"e_1_2_1_25_1","first-page":"183","article-title":"The distribution of uterine macrophages in virgin and early pregnant mice","volume":"179","author":"Stewart I. J.","year":"1991","journal-title":"J. Anat."},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1242\/dev.114.2.303","article-title":"Embryonic stern\u2010cell\u2010derived cystic embryoid bodies form vascular channels: an in vitro model of blood vessel development","volume":"114","author":"Wang R.","year":"1992","journal-title":"Development"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001920404"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.111.2.259"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910560317","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910560317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T15:16:12Z","timestamp":1695827772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910560317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,2]]}},"alternative-id":["10.1002\/ijc.2910560317"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910560317","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2]]}}}