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In cultured cancer cells, its production can be influenced by various factors or ions, but the regulation of its production is still poorly understood. We investigated the effects of stimulators of cAMP synthesis on PTHrP release by a human lung squamous\u2010carcinoma cell line (BEN). In supervised cells grown on microcarrier beads, PTHrP production was significantly increased after incubation with calcitonin for only 20 min. The release of immunoreactive and bioactive PTHrP was increased by incubating the cells with forskolin, 3\u2010isobutyl\u2010I\u2010methylxanthine or dibutyryl cAMP even in the presence of the protein\u2010synthesis inhibitor cycloheximide for 6 hr. The calcitonin\u2010mediated stimulation was not accompanied by. concomitant changes in PTHrP mRNA. The microfilament\u2010disrupter cytocha\u2010lasin D was shown to enhance the basal and calcitonin\u2010induced production of PTHrP. These results indicate that stimulators of cAMP synthesis enhanced PTHrP release by BEN cells.<\/jats:p>","DOI":"10.1002\/ijc.2910560323","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:38:50Z","timestamp":1171928330000},"page":"422-426","source":"Crossref","is-referenced-by-count":10,"title":["Cyclic AMP increases the release of parathyroid hormone\u2010related protein from a lung\u2010cancer cell line"],"prefix":"10.1002","volume":"56","author":[{"given":"Ren\u00e9","family":"Rizzoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel Lucien","family":"Aubert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Pascal","family":"Sappino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Philippe","family":"Bonjour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198809013190906"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.03.110187.001331"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1988.7.261"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend-3-3-503"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-125-1-563"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1975.237"},{"key":"e_1_2_1_8_1","first-page":"1311","article-title":"Properties of a calcitonin receptor and adenylate cyclase in BEN cells, a human cancer cell line","volume":"40","author":"Findlay D. 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