{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:39:11Z","timestamp":1762375151454},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4476,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1994,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The population of Linxian in China has one of the world's highest rates for esophageal\/gastric cardia cancer, as well as documented nutritional deficiencies. To determine whether dietary supplementation with a multi\u2010vitamin multi\u2010mineral preparation could reduce the risk of esophageal cancer and favorably influence precursor lesions, 3,318 individuals age 40\u201069 with cytologically determined grade I or grade 2 esophageal dysplasia were randomly assigned to receive either an active multi\u2010vitamin multi\u2010mineral supplement or a placebo. Pills were distributed at monthly visits and incident cancers or deaths were recorded. At 30 and 72 months subsequent to randomization all living participants without a known incident cancer were asked to undergo repeat cytological examination of their esophagus. Based on these procedures participants were classified as having no dysplasia, dysplasia grade I, dysplasia grade 2 or near cancer dysplasia. Diagnoses of cancer were based on the cytology findings plus available histologic, radio\u2010logic and clinical materials. At the end of the study there was little overall difference in cumulative risk of esophageal cancer between those receiving vitamin\/mineral supplementation and those receiving placebo. There was, however, a significant increase in reversion to non\u2010dysplastic cytology among the group receiving the active treatment. The odds of not having any dysplasia at the two post\u2010randomization screens was 1.23 times higher in the active treatment group than in the placebo group. Within each treatment group higher categories of dysplasia were associated with higher rates of cancer. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910570205","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:09:48Z","timestamp":1171930188000},"page":"162-166","source":"Crossref","is-referenced-by-count":29,"title":["The effect of vitamin and mineral supplementation on esophageal cytology: Results from the linxian dysplasia trial"],"prefix":"10.1002","volume":"57","author":[{"given":"Steven D.","family":"Mark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu Fan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Yao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell H.","family":"Gail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanford M.","family":"Dawsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fusheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Blot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"183","article-title":"Esophageal cytology and subsequent risk of esophageal cancer: a prospective follow\u2010up study from Linxian, China","volume":"38","author":"Dawsey S. M.","year":"1994","journal-title":"Acta. cytol."},{"key":"e_1_2_1_3_1","first-page":"l67","article-title":"Effects of vitamin\/mineral supplementation on the prevalence of histologic dysplasia and early cancer of the esophagus and stomach: results from the Dysplasia Trial in Linxian, China. Cancer Epidemiol","volume":"3","author":"Dawsey S. M.","year":"1994","journal-title":"Biomarkers Prev."},{"key":"e_1_2_1_4_1","volume-title":"Nonparametric statistical methods","author":"Hollander M.","year":"1973"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529309"},{"key":"e_1_2_1_6_1","first-page":"113","article-title":"Epidemiology of esophageal cancer in China","volume":"62","author":"Li J. Y.","year":"1982","journal-title":"Nat. Cancer Inst. Monogr."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.18.1492"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(93)90078-I"},{"key":"e_1_2_1_9_1","volume-title":"Statistical analysis with missing data","author":"Little R. J. A.","year":"1987"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","unstructured":"Mark S. D.andGail M. H. A comparison of likelihood\u2010based and marginal estimating equation methods for analyzing repeat ordered categorical responses with missing data: an application to an intervention trial of vitamin prophylaxis for esophageal dysplasia.Stat. Med.(1994) (In press).","DOI":"10.1002\/sim.4780130511"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910540204"},{"key":"e_1_2_1_12_1","first-page":"7","article-title":"Cytopathology of the esophagus: an overview of esophageal cytology in China","volume":"27","author":"Shu Y. J.","year":"1983","journal-title":"Acta. cytol."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910570205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910570205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T18:54:04Z","timestamp":1695840844000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910570205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4,15]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,4,15]]}},"alternative-id":["10.1002\/ijc.2910570205"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910570205","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4,15]]}}}