{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T12:46:44Z","timestamp":1742388404383},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":4477,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1994,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the distribution of <jats:sup>111<\/jats:sup>In\u2010pentetreotide (Octreoscan, Mallinckrodt) in nude mice xenografted with a human neuroblastoma cell line (SKLAN, derived from the LAN I line). These cells develop into solid tumours in nude mice and can be grafted repeatedly in grafts of 10<jats:sup>8<\/jats:sup> cells. Animals were sequentially explored by scintigraphy 2, 4, 24 and 48 hr after i.v. injection of 2.5\u20104 MBq of the tracer and killed at various times up to 46 hr. <jats:sup>111<\/jats:sup>In\u2010pentetreotide was rapidly and strongly taken up by all tumours, with a tumour\/muscle (T\/M) ratio on resected samples of 20.0 \u00b1 5.7 at 2 hr, 23.7 \u00b1 3.0 at 4 hr, 75.6 \u00b1 12.6 at 24 hr and 78.7 \u00b1 12.4 at 48 hr, for tumours ranging from 0.5 to 8 g. Scintigraphy results were quantitatively in agreement Pre\u2010injection of a 15\u201020 times larger quantity of unlabelled octreotide s.c. reduced the tumour uptake by a factor of 2. For comparison, nude mice xenografted with the same cell line were also studied with <jats:sup>123<\/jats:sup>I\u2010MIBG (4 MBq). At 24 hr, the T\/M ratio was 0.62 \u00b1 0.18. Two other cell lines (glioblastoma ROM and small\u2010cell lung carcinoma SC41) which were similarly tested with <jats:sup>111<\/jats:sup>In\u2010pentetreotide (2.5\u20104 MBq) gave T\/M ratios at 24 hr of 4.8 \u00b1 2.8 and 38.4 \u00b1 21.8, respectively. Pentetreotide seems to have a high affinity for this MIBG\u2010negative neuroblastoma cell line, which exhibited a clearly higher tumour uptake than the 2 other lines. This work provides new experimental arguments in favour of the particular interest of somatostatin analogues in neuroblastoma and confirms our first clinical results. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910570219","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:09:48Z","timestamp":1171930188000},"page":"245-246","source":"Crossref","is-referenced-by-count":9,"title":["Strong uptake of <sup>111<\/sup>in\u2010pentetreotide by an MIBG\u2010negative, xenografted neuroblastoma"],"prefix":"10.1002","volume":"57","author":[{"given":"L.","family":"Manil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Perdereau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Barbaroux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Buixy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"621","article-title":"Heterogeneous expression of oncogenes in small\u2010cell lung cancer xenografts","volume":"2","author":"Arvelo F.","year":"1993","journal-title":"Int. J. Oncol."},{"key":"e_1_2_1_3_1","first-page":"737","article-title":"In\u2010111 labeled for tumor imaging. Initial results in neuroblastoma. EANM congress. Lissbon. Portugal, August 32\u201326, in","volume":"19","author":"Beriele B.","year":"1992","journal-title":"Eur. J. Nucl. Med."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00209003"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91258-0"},{"key":"e_1_2_1_6_1","first-page":"176","article-title":"Somatostatin receptor scintigraphy with (111In\u2010DTPA\u2010D\u2010Phe1)\u2010and 123I\u2010Tyr3)\u2010octreotide: the Rotterdam experience with more that 1,000 patients","volume":"20","author":"Krenning E. P.","year":"1993","journal-title":"Europ. J. nucl. 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