{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:19:35Z","timestamp":1790417975873,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":4461,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Burkitt lymphoma (BL) tumour\u2010cell populations are known to display high rates both of proliferation and of apoptosis in vivo, but the mechanisms which determine whether a BL cell continues to cycle or engages its cell\u2010death programme are not understood. Group\u2010I BL\u2010derived cell lines, which retain in vitro the proliferateve and apoptotic capacities of the parental cells, selectively entered apoptosis when returned to 37\u00b0C after a brief period at low temperature (1\u00b0C). The induction of apoptosis by cold treatment, as determined by morphological characteristics and DNA fragmentation, was readily detectable within the first 1 to 2 hr of re\u2010incubation at 37\u00b0C, reaching a maximum at 4 to 6 hours. Commitment to enter apoptosis occurred after as little as 20 to 30 min at 1\u00b0C. Significant cell death at 1\u00b0C occurred only during prolonged incubation in the cold and displayed the characteristics of necrosis. Both bc1\u20102\u2010dependent and \u2010independent survival pathways were found to provide protection from cold\u2010induced apoptosis, but only if engaged before cold\u2010shock treatment. These results indicate that continued cycling of group\u20101 BL cells is dependent upon their capacity to inhibit or circumvent their normally constitutively active apoptotic programme, and are consistent with the notion that the synthesis of one or more critical \u201csurvival\u201d proteins of short half\u2010life is necessary to guarantee successful passage through the cell cycle. Notably, high levels of apoptosis were also inducible in group\u20101 BL cells by inhibitors of RNA and protein synthesis. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910570321","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:09:23Z","timestamp":1171930163000},"page":"419-426","source":"Crossref","is-referenced-by-count":45,"title":["Regulation of cell survival in burkitt lymphoma: Implications from studies of apoptosis following cold\u2010shock treatment"],"prefix":"10.1002","volume":"57","author":[{"given":"Christopher D.","family":"Gregory","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Milner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1915","article-title":"Constitutive c\u2010myc expression in an IL\u20103\u2010dependent myeloid cell line suppresses cell\u2010cycle arrest and accelerates apoptosis","volume":"6","author":"Askew D. 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