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The finding that IFN\u2010\u03b1\/\u03b2 therapy increased the survival time of ESb\u2010tmmunized mice rechallenged with ESb cells suggested that cooperation between the immune system and IFN\u2010\u03b1\/\u03b2 was important. Adoptive transfer of ESb\u2010immune spleen cells (but not normal cells) together with IFN\u2010\u03b1\/\u03b2 treatment did inhibit the development of ESb metastases in immunocompetent DBA\/2 mice. Either treatment alone was ineffective. The anti\u2010metastatic effect was specific for the ESb lymphoma as spleen cells from ESb\u2010immunized mice together with IFN\u2010\u03b1\/\u03b2 treatment did not inhibit the development of metastases in mice challenged with IFN\u2010\u03b1\/\u03b2\u2010resistant 3C18 FLC. Depletion of CD8<jats:sup>+<\/jats:sup> T cells (but not CD4<jats:sup>+<\/jats:sup> T cells or B lymphocytes) prior to transfer eliminated the protective effect of ESb\u2010immune splenocytes in IFN\u2010\u03b1\/\u03b2\u2010treated mice. As few as 1 \u00d7 10<jats:sup>6<\/jats:sup> ESb\u2010immune spleen cells highly enriched for CD8<jats:sup>+<\/jats:sup> cells increased the survival time of IFN\u2010\u03b1\/\u03b2\u2010treated ESb\u2010challenged DBA\/2 mice. The combined therapy of ESb\u2010specific immune cells and IFN\u2010\u03b1\/\u03b2 resulted in long\u2010term immunity to this tumor. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910570417","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:06:02Z","timestamp":1171929962000},"page":"538-543","source":"Crossref","is-referenced-by-count":20,"title":["Successful immunotherapy of the highly metastatic murine ESb lymphoma with sensitized CD8<sup>+<\/sup> T cells and IFN\u2010\u03b1\/\u03b2"],"prefix":"10.1002","volume":"57","author":[{"given":"Thomas","family":"Kaido","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal","family":"Maury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Schirrmacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ion","family":"Gresser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.3.647"},{"key":"e_1_2_1_3_1","first-page":"159","article-title":"Changes in tumor cell adhesiveness affecting speed of dissemination and mode of metastatic growth","volume":"8","author":"Benke R.","year":"1988","journal-title":"Inv. 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