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It was shown earlier that a larger number of cells can be induced to enter the lytic cycle by exposing P3HR\u20101 to phorbol esters and n\u2010butyrate and the surface IgG\u2010positive Akata cells to anti\u2010IgG. We now show that the same treatments raise the level of active TGF\u00df release. Exposure to anti\u2010TGF\u00df antibodies reduced EA induction by 75\u201085%. Our results indicate that induction of the viral productive cycle by the above\u2010mentioned reagents is at least partly dependent on the activation of endogenous TGF\u00df production. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910570623","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:05:19Z","timestamp":1171929919000},"page":"914-919","source":"Crossref","is-referenced-by-count":54,"title":["Endogenous TGF\u2010\u03b2 contributes to the induction of the EBV lytic cycle in two burkitt lymphoma cell lines"],"prefix":"10.1002","volume":"57","author":[{"given":"Livia","family":"di Renzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysin","family":"Alttok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/08977199109000263"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830150407"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(82)90128-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/08977199009037500"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(88)90127-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.3.1039"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(88)90011-5"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041380112"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.8.4001"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-124-31677"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910100108"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90193-0"},{"key":"e_1_2_1_14_1","first-page":"184","article-title":"Normal embryo fibroblasts release transforming growth factor beta factors in a latent form","volume":"121","author":"Lawrence D. 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