{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T05:05:24Z","timestamp":1698469524245},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4385,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1994,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twenty\u2010six established Burkitt's lymphoma (BL) cell lines from endemic or sporadic groups of patients were examined for the expression of cross\u2010reactive idiotypes (CRI) associated with V<jats:sub>H<\/jats:sub>I, V<jats:sub>H<\/jats:sub>III, V<jats:sub>H<\/jats:sub>IV, V<jats:sub>H<\/jats:sub>VI, V<jats:sub>K<\/jats:sub>IIIa and V<jats:sub>K<\/jats:sub>IIIb heavy\u2010and light\u2010chain gene products, using a panel of anti\u2010CRI and anti\u2010subgroup monoclonal antibodies (MAbs). Membrane, cytoplasmic and secreted immunoglobulins (Ig) were analysed by immunofluorescence, immunoperoxidase and ELISA respectively. While 35% of the lines expressed either of the V<jats:sub>H<\/jats:sub>IV\u2010associated CRI, recognised by the MAbs 9G4 or LCI, none expressed the other V<jats:sub>H<\/jats:sub>\u2010associated CRI included in our study. Of the kappa light chain expressing BL lines 54% and 46% belonged to the V<jats:sub>K<\/jats:sub>III subgroup and V<jats:sub>K<\/jats:sub>IIIb sub\u2010subgroups respectively. None, however, was found to express the V<jats:sub>K<\/jats:sub>IIIa or V<jats:sub>K<\/jats:sub>IIIb\u2010associated CRI, recognised by the 6B6.6 and 17\u2010109 MAbs. A significant association has been observed between the expression of the V<jats:sub>H<\/jats:sub>IV\u2010associated CRI and the V<jats:sub>K<\/jats:sub>III subgroup within the BL lines derived from the sporadic group of patients as compared with their endemic counterparts. Our results suggest that the expressed repertoire of Ig variable region genes within the malignant B lymphocytes of BL is not random and that a highly selective mechanism(s) may operate on this subset of B lymphocytes, as evidenced by the expression of the V<jats:sub>H<\/jats:sub> and V<jats:sub>K<\/jats:sub> gene products.<\/jats:p>","DOI":"10.1002\/ijc.2910580214","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:23:13Z","timestamp":1171930993000},"page":"226-232","source":"Crossref","is-referenced-by-count":8,"title":["Biased utilization of immunoglobulin variable region heavy\u2010 and light\u2010chain genes by the malignant CD5\u2010 B lymphocytes from patients with Burkitt's lymphoma"],"prefix":"10.1002","volume":"58","author":[{"given":"Mohammad","family":"Moazzeni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghasem","family":"Mosayyebi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freda K.","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Abbot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizgar A.","family":"Mageed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fazel","family":"Shokri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.4049\/jimmunol.129.3.1336","article-title":"Immunoglobulin secretion by cell lines derived from African and American undifferentiated lymphomas of Burkitt's and non\u2010Burkitt's types","volume":"129","author":"Benjamin D.","year":"1982","journal-title":"J. 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