{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:34:26Z","timestamp":1780475666390,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4368,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1994,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a previous investigation, statistical modelling was used to examine the relationship between large\u2010bowel\u2010cancer incidence and age, time period and birth cohort by anatomic sub\u2010site and sex, using data from the Connecticut Tumor Registry (CTR) for the period 1950 to 1984. This analysis revealed differences in age\u2010period\u2010cohort patterns that suggested etiologic distinctions among sub\u2010site groupings and between the sexes. To test the generalizability of the Connecticut findings, we have conducted a similar age\u2010period\u2010cohort analysis using data from the Danish Cancer Registry (DCR) for the period 1953 to 1987. Cancers of the large bowel were classified into 6 anatomic sub\u2010sites: cecum, ascending colon, transverse colon, descending colon, sigmoid colon and rectum. Data were fitted to log\u2010linear age\u2010period\u2010cohort models. If we interpret differences in age\u2010period\u2010cohort patterns as reflecting etiologic distinctions, the Denmark analysis, in conjunction with the Connecticut findings, was consistent with there being etiologic distinctions between cancers of the colon <jats:italic>vs.<\/jats:italic> the rectum in both males and females, between cancers of the cecum and the ascending colon <jats:italic>vs.<\/jats:italic> the remainder of the colon in females and between males <jats:italic>vs.<\/jats:italic> females for cancers of the sigmoid colon and rectum. Cancers of the cecum and the ascending colon were the most similar between males and females. Due to the ambiguities of age\u2010period\u2010cohort modelling, these should be considered only tentative conclusions that can be tested by analytical epidemiologic studies.<\/jats:p>","DOI":"10.1002\/ijc.2910580303","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:23:06Z","timestamp":1171930986000},"page":"324-329","source":"Crossref","is-referenced-by-count":14,"title":["Age\u2010period\u2010cohort modelling of large\u2010bowel\u2010cancer incidence by anatomic sub\u2010site and sex in Denmark"],"prefix":"10.1002","volume":"58","author":[{"given":"Robert","family":"Dubrow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffer","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Skov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore R.","family":"Holford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Statistical modelling in GLIM","author":"Aitkin M.","year":"1989"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02553382"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-10-779"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60086-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910100305"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930615)71:12<3819::AID-CNCR2820711206>3.0.CO;2-L"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/oxfordjournals.aje.a116773","article-title":"Sex differences in the risks of hormone\u2010dependent cancers","volume":"138","author":"Dos Santos Silva I.","year":"1993","journal-title":"Amer. J. Epidemiol."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910530607"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.43.4.356"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841869009096379"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531004"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pu.12.050191.002233"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1984.262"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00341276"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00056213"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089169107700313"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02564165"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113672"},{"key":"e_1_2_1_20_1","volume-title":"Cancer incidence in five continents","author":"Muir C.","year":"1987"},{"key":"e_1_2_1_21_1","volume-title":"Cancer risk and incidence trends\u2014the Connecticut perspective","author":"Roush G. C.","year":"1987"},{"key":"e_1_2_1_22_1","first-page":"216","article-title":"Changing distribution of carcinoma of the colon and rectum","volume":"158","author":"Slater G. I.","year":"1984","journal-title":"Surg. Gynecol. Obst."},{"key":"e_1_2_1_23_1","volume-title":"Cancer incidence in Denmark 1988","author":"Storm H. H.","year":"1991"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19841215)54:12<3065::AID-CNCR2820541242>3.0.CO;2-C"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901201)66:11<2442::AID-CNCR2820661134>3.0.CO;2-5"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910580303","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910580303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T17:01:22Z","timestamp":1698166882000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910580303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,8]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,8]]}},"alternative-id":["10.1002\/ijc.2910580303"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910580303","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,8]]}}}