{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:25:25Z","timestamp":1792074325200,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4307,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two different oncofetal fibronectins (FN) have been reported: one, generated by O\u2010glycosylation in the splicing region IIICS that is recognized by monoclonal antibody (MAb) FDC\u20106, and another, recognized by MAb BC\u2010I, generated by the alternative splicing of the FN pre\u2010mRNA which includes an extra type\u2010III repeat called ED\u2010B. Using these and 2 other MAbs (IST\u20104 which recognizes all different FN isoforms and IST\u20106 which recognizes only the FN molecules that do not include the ED\u2010B sequence) we have immunohistochemically studied 171 normal, hyperplastic and neoplastic breast\u2010tissue specimens. Although all normal specimens reacted strongly with MAbs IST\u20104 and IST\u20106, they did not show the presence of oncofetal FNs as established by the use of BC\u20101 and FDC\u20106. In contrast, out of the 97 cases of invasive ductal carcinomas studied, 90 (93%) and 96 (99%) reacted positively with BC\u2010I and FDC\u20106, respectively, the reaction being observed in the tumoral stroma connective tissue and in tumoral vessels. Furthermore, invasive lobular carcinoma showed less intense and less frequent staining with BC\u20101 and FDC\u20106 (10 and 11 out of 14, respectively). We found differences in the distribution of the 2 oncofetal fibronectin isoforms within the same specimens. The most remarkable difference was observed in the tumoral vessels: in invasive ductal carcinoma MAb BC\u20101 revealed a positive reaction with vessels in 78% of cases while FDC\u20106 showed such a reaction in only 59% of cases.<\/jats:p>","DOI":"10.1002\/ijc.2910590104","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:19:30Z","timestamp":1171930770000},"page":"11-16","source":"Crossref","is-referenced-by-count":121,"title":["Distribution of oncofetal fibronectin isoforms in normal, hyperplastic and neoplastic human breast tissues"],"prefix":"10.1002","volume":"59","author":[{"given":"Janusz","family":"Kaczmarek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Castellani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Nicolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Spina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Allemanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Zardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"3314","article-title":"Histological grading and prognosis in breast cancer: a study of 1,409 cases of which 359 have been followed for 15 years","volume":"263","author":"Bloom J. 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