{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:53:20Z","timestamp":1761310400048},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4307,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mutations in the first and second exons of Ha\u2010, Ki\u2010 and N\u2010<jats:italic>ras<\/jats:italic> oncogenes were investigated in 17 epithelial tumors of the ampulla of Vater by single\u2010strand conformation polymorphism analysis and direct sequencing of DNA fragments amplified by polymerase chain reaction. The panel included 12 intestinaltype adenocarcinomas, 3 villous adenomas, I papillary carcinoma and I neuroendocrine carcinoma. Six cases (35%) contained <jats:italic>ras<\/jats:italic> mutations, affecting codon 12 of Ki\u2010<jats:italic>ras<\/jats:italic> in 2 adenomas and 3 carcinomas, and of N\u2010<jats:italic>ras<\/jats:italic> in I adenoma. All mutations were found in adenomas and among cancers with adenomatous areas, whereas none of the cases lacking adenomatous areas contained mutations. This suggested that ampullary cancers represent heterogeneous diseases with respect to the presence or absence of adenomatous areas and, among those with adenomatous areas, with respect to the presence of activated <jats:italic>ras<\/jats:italic> genes. Ki\u2010<jats:italic>ras<\/jats:italic> mutated cases included 3 of 4 tumors which mainly involved the intraduodenal bile duct, thus suggesting that a proportion of Ki\u2010<jats:italic>ras<\/jats:italic> \u2010mutated ampullary cancers might correspond to those originating from the epithelium of the bile duct component of the ampulla.<\/jats:p>","DOI":"10.1002\/ijc.2910590109","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:19:30Z","timestamp":1171930770000},"page":"39-42","source":"Crossref","is-referenced-by-count":38,"title":["<i>ras<\/i>\u2010family gene mutations in neoplasia of the ampulla of vater"],"prefix":"10.1002","volume":"59","author":[{"given":"Aldo","family":"Scarpa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Zamboni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Achille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Capelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Bogina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calogero","family":"Iacono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Serio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto S.","family":"Accolla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(85)80018-6"},{"key":"e_1_2_1_3_1","first-page":"853","article-title":"Major duodenal papilla: variation of histopathologic interest and lesions of the mucosa","volume":"26","author":"Baggenstoss A.","year":"1988","journal-title":"Arch. 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